ECE1 protein (Canis lupus familiaris) - STRING interaction network

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Score

ECE1

Endothelin converting enzyme 1. (792 aa)

Predicted Functional Partners:

EDN1

0.943

IDE

0.744

EDNRB

0.734

EDNRA

0.716

EEF1AKMT4

0.708

CPVL

0.680

HP1BP3

0.643

EDN2

0.597

EDN3

0.588

NPEPL1

0.579

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPVL	ECE1	ENSCAFP00000004492	ENSCAFP00000048128	Carboxypeptidase vitellogenic like; Belongs to the peptidase S10 family.	Endothelin converting enzyme 1.	0.680
ECE1	CPVL	ENSCAFP00000048128	ENSCAFP00000004492	Endothelin converting enzyme 1.	Carboxypeptidase vitellogenic like; Belongs to the peptidase S10 family.	0.680
ECE1	EDN1	ENSCAFP00000048128	ENSCAFP00000014389	Endothelin converting enzyme 1.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.943
ECE1	EDN2	ENSCAFP00000048128	ENSCAFP00000003751	Endothelin converting enzyme 1.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.597
ECE1	EDN3	ENSCAFP00000048128	ENSCAFP00000018044	Endothelin converting enzyme 1.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.588
ECE1	EDNRA	ENSCAFP00000048128	ENSCAFP00000011497	Endothelin converting enzyme 1.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.716
ECE1	EDNRB	ENSCAFP00000048128	ENSCAFP00000007760	Endothelin converting enzyme 1.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.734
ECE1	EEF1AKMT4	ENSCAFP00000048128	ENSCAFP00000018453	Endothelin converting enzyme 1.	EEF1A lysine methyltransferase 4.	0.708
ECE1	HP1BP3	ENSCAFP00000048128	ENSCAFP00000054328	Endothelin converting enzyme 1.	Heterochromatin protein 1 binding protein 3.	0.643
ECE1	IDE	ENSCAFP00000048128	ENSCAFP00000011097	Endothelin converting enzyme 1.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.744
ECE1	NPEPL1	ENSCAFP00000048128	ENSCAFP00000037463	Endothelin converting enzyme 1.	Aminopeptidase like 1.	0.579
EDN1	ECE1	ENSCAFP00000014389	ENSCAFP00000048128	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin converting enzyme 1.	0.943
EDN1	EDN2	ENSCAFP00000014389	ENSCAFP00000003751	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.924
EDN1	EDN3	ENSCAFP00000014389	ENSCAFP00000018044	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.938
EDN1	EDNRA	ENSCAFP00000014389	ENSCAFP00000011497	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.999
EDN1	EDNRB	ENSCAFP00000014389	ENSCAFP00000007760	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.999
EDN2	ECE1	ENSCAFP00000003751	ENSCAFP00000048128	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Endothelin converting enzyme 1.	0.597
EDN2	EDN1	ENSCAFP00000003751	ENSCAFP00000014389	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.924
EDN2	EDN3	ENSCAFP00000003751	ENSCAFP00000018044	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.927
EDN2	EDNRA	ENSCAFP00000003751	ENSCAFP00000011497	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.974