STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TBC1D16TBC1 domain family member 16. (768 aa)    
Predicted Functional Partners:
PPM1L
Protein phosphatase, Mg2+/Mn2+ dependent 1L.
   
  
 0.875
RAB4A
RAB4A, member RAS oncogene family.
    
 0.859
TBC1D10C
TBC1 domain family member 10C.
      
0.719
TBC1D19
TBC1 domain family member 19.
      
 0.678
TBC1D20
TBC1 domain family member 20.
      
 0.677
RAB27A
Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
      
 0.648
TBC1D8
TBC1 domain family member 8.
      
 0.647
EVI5
Rab-GAP TBC domain-containing protein.
      
0.640
TBC1D7
TBC1 domain family member 7.
      
 0.635
TBC1D1
TBC1 domain family member 1.
      
0.525
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.