STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NDEL1NudE neurodevelopment protein 1 like 1. (466 aa)    
Predicted Functional Partners:
DISC1
DISC1 scaffold protein.
    
 
 0.893
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]
   
 
 0.869
NUDC
Nuclear distribution C, dynein complex regulator.
   
 
 0.857
PLK1
Serine/threonine-protein kinase PLK.
     
 0.832
BORCS6
BLOC-1 related complex subunit 6.
    
 
 0.804
CDC20
Cell division cycle 20.
     
  0.800
MPDU1
Mannose-P-dolichol utilization defect 1.
   
  
 0.713
DIXDC1
DIX domain containing 1.
    
 
 0.706
CENPF
Centromere protein F.
    
 
 0.698
SMU1
SMU1 DNA replication regulator and spliceosomal factor.
   
  
 0.682
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.