STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAK1AP2 associated kinase 1. (1055 aa)    
Predicted Functional Partners:
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
 
 0.781
AP2B1
AP complex subunit beta.
   
 
 0.750
COQ8B
Coenzyme Q8B.
   
 
 0.652
NUMB
NUMB endocytic adaptor protein.
    
 
 0.638
PDXDC1
Pyridoxal dependent decarboxylase domain containing 1.
   
  
 0.616
AP2S1
Adaptor related protein complex 2 subunit sigma 1.
   
 
 0.609
DBNL
Drebrin like.
    
 
 0.594
DBN1
Drebrin 1.
    
 
 0.594
ENSCAFP00000066248
Uncharacterized protein.
    
 
 0.590
EPS15
Epidermal growth factor receptor pathway substrate 15.
   
 
 0.576
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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