SEMA4D protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

SEMA4D

Semaphorin 4D; Belongs to the semaphorin family. (1067 aa)

Predicted Functional Partners:

PLXNB1

0.998

PLXNB3

0.991

CD72

0.986

PTPRC

0.926

PLXNB2

0.908

RRAS

0.835

NTN3

0.789

PLXNC1

0.776

PLXNA2

0.717

MET

0.717

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD72	SEMA4D	ENSCAFP00000003036	ENSCAFP00000050019	CD72 molecule.	Semaphorin 4D; Belongs to the semaphorin family.	0.986
MET	PLXNB1	ENSCAFP00000041478	ENSCAFP00000018777	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B1.	0.932
MET	PLXNB3	ENSCAFP00000041478	ENSCAFP00000028445	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B3.	0.932
MET	RRAS	ENSCAFP00000041478	ENSCAFP00000044955	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	RAS related.	0.657
MET	SEMA4D	ENSCAFP00000041478	ENSCAFP00000050019	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Semaphorin 4D; Belongs to the semaphorin family.	0.717
NTN3	SEMA4D	ENSCAFP00000028607	ENSCAFP00000050019	Netrin 3.	Semaphorin 4D; Belongs to the semaphorin family.	0.789
PLXNA2	SEMA4D	ENSCAFP00000001999	ENSCAFP00000050019	Plexin A2.	Semaphorin 4D; Belongs to the semaphorin family.	0.717
PLXNB1	MET	ENSCAFP00000018777	ENSCAFP00000041478	Plexin B1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.932
PLXNB1	PLXNB3	ENSCAFP00000018777	ENSCAFP00000028445	Plexin B1.	Plexin B3.	0.904
PLXNB1	RRAS	ENSCAFP00000018777	ENSCAFP00000044955	Plexin B1.	RAS related.	0.950
PLXNB1	SEMA4D	ENSCAFP00000018777	ENSCAFP00000050019	Plexin B1.	Semaphorin 4D; Belongs to the semaphorin family.	0.998
PLXNB2	RRAS	ENSCAFP00000000964	ENSCAFP00000044955	Plexin B2.	RAS related.	0.675
PLXNB2	SEMA4D	ENSCAFP00000000964	ENSCAFP00000050019	Plexin B2.	Semaphorin 4D; Belongs to the semaphorin family.	0.908
PLXNB3	MET	ENSCAFP00000028445	ENSCAFP00000041478	Plexin B3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.932
PLXNB3	PLXNB1	ENSCAFP00000028445	ENSCAFP00000018777	Plexin B3.	Plexin B1.	0.904
PLXNB3	RRAS	ENSCAFP00000028445	ENSCAFP00000044955	Plexin B3.	RAS related.	0.950
PLXNB3	SEMA4D	ENSCAFP00000028445	ENSCAFP00000050019	Plexin B3.	Semaphorin 4D; Belongs to the semaphorin family.	0.991
PLXNC1	RRAS	ENSCAFP00000009304	ENSCAFP00000044955	Plexin C1.	RAS related.	0.451
PLXNC1	SEMA4D	ENSCAFP00000009304	ENSCAFP00000050019	Plexin C1.	Semaphorin 4D; Belongs to the semaphorin family.	0.776
PTPRC	SEMA4D	ENSCAFP00000054600	ENSCAFP00000050019	Protein tyrosine phosphatase receptor type C.	Semaphorin 4D; Belongs to the semaphorin family.	0.926