SPATA17 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

SPATA17

Spermatogenesis associated 17. (392 aa)

Predicted Functional Partners:

LOC484344

0.875

LOC476396

0.871

COL23A1

0.806

MATN2

0.806

GPATCH2

0.773

KCTD3

0.771

RRP15

0.770

PGRMC2

0.724

LOC102152131

0.689

GLIPR1L2

0.683

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL23A1	LOC102152131	ENSCAFP00000041451	ENSCAFP00000004186	Collagen type XXIII alpha 1 chain.	Uncharacterized protein.	0.562
COL23A1	LOC476396	ENSCAFP00000041451	ENSCAFP00000044910	Collagen type XXIII alpha 1 chain.	Uncharacterized protein.	0.802
COL23A1	LOC484344	ENSCAFP00000041451	ENSCAFP00000004189	Collagen type XXIII alpha 1 chain.	Uncharacterized protein.	0.802
COL23A1	MATN2	ENSCAFP00000041451	ENSCAFP00000065280	Collagen type XXIII alpha 1 chain.	Matrilin 2.	0.682
COL23A1	PGRMC2	ENSCAFP00000041451	ENSCAFP00000034415	Collagen type XXIII alpha 1 chain.	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family.	0.575
COL23A1	SPATA17	ENSCAFP00000041451	ENSCAFP00000050043	Collagen type XXIII alpha 1 chain.	Spermatogenesis associated 17.	0.806
GLIPR1L2	SPATA17	ENSCAFP00000039125	ENSCAFP00000050043	GLIPR1 like 2.	Spermatogenesis associated 17.	0.683
GPATCH2	KCTD3	ENSCAFP00000015871	ENSCAFP00000061195	G-patch domain containing 2.	Potassium channel tetramerization domain containing 3.	0.781
GPATCH2	RRP15	ENSCAFP00000015871	ENSCAFP00000015941	G-patch domain containing 2.	Ribosomal RNA processing 15 homolog.	0.787
GPATCH2	SPATA17	ENSCAFP00000015871	ENSCAFP00000050043	G-patch domain containing 2.	Spermatogenesis associated 17.	0.773
KCTD3	GPATCH2	ENSCAFP00000061195	ENSCAFP00000015871	Potassium channel tetramerization domain containing 3.	G-patch domain containing 2.	0.781
KCTD3	RRP15	ENSCAFP00000061195	ENSCAFP00000015941	Potassium channel tetramerization domain containing 3.	Ribosomal RNA processing 15 homolog.	0.782
KCTD3	SPATA17	ENSCAFP00000061195	ENSCAFP00000050043	Potassium channel tetramerization domain containing 3.	Spermatogenesis associated 17.	0.771
LOC102152131	COL23A1	ENSCAFP00000004186	ENSCAFP00000041451	Uncharacterized protein.	Collagen type XXIII alpha 1 chain.	0.562
LOC102152131	LOC476396	ENSCAFP00000004186	ENSCAFP00000044910	Uncharacterized protein.	Uncharacterized protein.	0.426
LOC102152131	LOC484344	ENSCAFP00000004186	ENSCAFP00000004189	Uncharacterized protein.	Uncharacterized protein.	0.412
LOC102152131	MATN2	ENSCAFP00000004186	ENSCAFP00000065280	Uncharacterized protein.	Matrilin 2.	0.523
LOC102152131	PGRMC2	ENSCAFP00000004186	ENSCAFP00000034415	Uncharacterized protein.	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family.	0.489
LOC102152131	SPATA17	ENSCAFP00000004186	ENSCAFP00000050043	Uncharacterized protein.	Spermatogenesis associated 17.	0.689
LOC476396	COL23A1	ENSCAFP00000044910	ENSCAFP00000041451	Uncharacterized protein.	Collagen type XXIII alpha 1 chain.	0.802

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.87e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030216

Keratinocyte differentiation

4 of 69

2.03

1.79

0.00028

GO:0043588

Skin development

5 of 156

1.77

1.76

0.00015

GO:0006672

Ceramide metabolic process

4 of 86

1.93

1.66

0.00043

GO:0031424

Keratinization

3 of 28

2.29

1.57

0.0011

GO:0046513

Ceramide biosynthetic process

3 of 51

2.03

1.29

0.0032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28815464

(2018) Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.

8 of 12

3.09

9.46

1.74e-18

PMID:31833240

(2020) Targeted regions sequencing identified four novel PNPLA1 mutations in two Chinese families with autosomal recessive congenital ichthyosis.

8 of 26

2.75

8.13

1.25e-16

PMID:28249031

(2017) A de novo variant in the ASPRV1 gene in a dog with ichthyosis.

6 of 11

3.0

6.41

1.16e-12

PMID:28122049

(2017) A Defect in NIPAL4 Is Associated with Autosomal Recessive Congenital Ichthyosis in American Bulldogs.

6 of 12

2.96

6.36

1.30e-12

PMID:34599683

(2021) A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle.

5 of 8

3.06

5.22

2.44e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33340

Mixed, incl. Magnesium ion transmembrane transport, and Keratinization

7 of 10

3.11

8.57

1.06e-16

CL:33344

Mixed, incl. Keratinization, and Apolipoprotein A-I receptor binding

5 of 5

3.26

6.13

6.22e-12

CL:13676

Mixed, incl. Winged helix Storkhead-box1 domain, and Hemimethylated DNA-binding protein YccV like

2 of 6

2.79

1.33

0.0038

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