STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INVSInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...] (1083 aa)    
Predicted Functional Partners:
DVL2
Dishevelled segment polarity protein 2.
   
 0.955
DVL1
Dishevelled segment polarity protein 1.
    
 0.946
DVL3
Dishevelled segment polarity protein 3.
   
 0.931
CEP290
Centrosomal protein 290.
   
 
 0.818
NPHP4
Nephrocystin 4.
   
 
 0.815
PRICKLE3
Prickle planar cell polarity protein 3.
   
 
 0.746
PSMD6
Prickle planar cell polarity protein 2.
   
 
 0.745
NEK8
NIMA related kinase 8.
   
 
 0.727
NPHP3
Nephrocystin 3.
   
 
 0.710
PRICKLE1
Prickle planar cell polarity protein 1.
   
 
 0.696
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.