RHEB protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RHEB

Ras homolog, mTORC1 binding. (232 aa)

Predicted Functional Partners:

TSC2

0.999

MTOR

0.991

TSC1

0.987

MLST8

0.981

RPTOR

0.976

BNIP3

0.974

DEPTOR

0.971

TBC1D7

0.970

AKT1S1

0.927

SARS1

0.875

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSCAFP00000005180	ENSCAFP00000001263	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.900
AKT1S1	MLST8	ENSCAFP00000005180	ENSCAFP00000030885	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.981
AKT1S1	MTOR	ENSCAFP00000005180	ENSCAFP00000024527	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.995
AKT1S1	RHEB	ENSCAFP00000005180	ENSCAFP00000050252	AKT1 substrate 1.	Ras homolog, mTORC1 binding.	0.927
AKT1S1	RPTOR	ENSCAFP00000005180	ENSCAFP00000008518	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.998
AKT1S1	TSC2	ENSCAFP00000005180	ENSCAFP00000038086	AKT1 substrate 1.	TSC complex subunit 2.	0.448
BNIP3	RHEB	ENSCAFP00000033658	ENSCAFP00000050252	BCL2 interacting protein 3.	Ras homolog, mTORC1 binding.	0.974
DEPTOR	AKT1S1	ENSCAFP00000001263	ENSCAFP00000005180	DEP domain containing MTOR interacting protein.	AKT1 substrate 1.	0.900
DEPTOR	MLST8	ENSCAFP00000001263	ENSCAFP00000030885	DEP domain containing MTOR interacting protein.	MTOR associated protein, LST8 homolog.	0.999
DEPTOR	MTOR	ENSCAFP00000001263	ENSCAFP00000024527	DEP domain containing MTOR interacting protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.996
DEPTOR	RHEB	ENSCAFP00000001263	ENSCAFP00000050252	DEP domain containing MTOR interacting protein.	Ras homolog, mTORC1 binding.	0.971
DEPTOR	RPTOR	ENSCAFP00000001263	ENSCAFP00000008518	DEP domain containing MTOR interacting protein.	Regulatory associated protein of MTOR complex 1.	0.999
DEPTOR	TSC2	ENSCAFP00000001263	ENSCAFP00000038086	DEP domain containing MTOR interacting protein.	TSC complex subunit 2.	0.649
MLST8	AKT1S1	ENSCAFP00000030885	ENSCAFP00000005180	MTOR associated protein, LST8 homolog.	AKT1 substrate 1.	0.981
MLST8	DEPTOR	ENSCAFP00000030885	ENSCAFP00000001263	MTOR associated protein, LST8 homolog.	DEP domain containing MTOR interacting protein.	0.999
MLST8	MTOR	ENSCAFP00000030885	ENSCAFP00000024527	MTOR associated protein, LST8 homolog.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.998
MLST8	RHEB	ENSCAFP00000030885	ENSCAFP00000050252	MTOR associated protein, LST8 homolog.	Ras homolog, mTORC1 binding.	0.981
MLST8	RPTOR	ENSCAFP00000030885	ENSCAFP00000008518	MTOR associated protein, LST8 homolog.	Regulatory associated protein of MTOR complex 1.	0.999
MLST8	TSC1	ENSCAFP00000030885	ENSCAFP00000029451	MTOR associated protein, LST8 homolog.	TSC complex subunit 1.	0.712
MLST8	TSC2	ENSCAFP00000030885	ENSCAFP00000038086	MTOR associated protein, LST8 homolog.	TSC complex subunit 2.	0.825