STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERGEFSecretion regulating guanine nucleotide exchange factor. (492 aa)    
Predicted Functional Partners:
DPH3
Diphthamide biosynthesis 3.
    
 
 0.973
OTOG
Otogelin.
      
 0.807
CNKSR3
Uncharacterized protein.
   
  
 0.740
KCNC1
Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family.
      
 0.672
CRTAM
Cytotoxic and regulatory T cell molecule.
   
  
 0.666
ABCC8
ATP binding cassette subfamily C member 8.
    
 
 0.615
RPS13
Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.
   
  
 0.613
USH1C
USH1 protein network component harmonin.
    
 
 0.601
SCN3B
Sodium voltage-gated channel beta subunit 3.
   
  
 0.589
ZNF677
Zinc finger protein 677.
   
 
 0.583
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.