STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PALLDPalladin, cytoskeletal associated protein. (1178 aa)    
Predicted Functional Partners:
LASP1
LIM and SH3 protein 1.
   
 
 0.704
EPS8
Epidermal growth factor receptor pathway substrate 8.
   
  
 0.638
CORO2B
Coronin; Belongs to the WD repeat coronin family.
   
 
 0.596
VASP
Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...]
    
 
 0.582
FLNA
Filamin A.
   
 
 0.571
TCAP
Titin-cap.
   
 
 0.541
CYB5D1
Cytochrome b5 domain containing 1; Belongs to the cytochrome b5 family.
      
 0.522
TACC2
Transforming acidic coiled-coil containing protein 2.
   
 
 0.515
AFAP1L2
Actin filament associated protein 1 like 2.
      
 0.504
MRPS31
Mitochondrial ribosomal protein S31.
    
 
 0.492
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.