TLL1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TLL1

Metalloendopeptidase. (1031 aa)

Predicted Functional Partners:

CHRD

0.719

IDE

0.619

OMA1

0.615

KEL

0.597

DCN

0.596

FURIN

0.591

MME

0.584

LNPEP

0.562

TTC14

0.526

TRHDE

0.517

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHRD	TLL1	ENSCAFP00000041950	ENSCAFP00000051087	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Metalloendopeptidase.	0.719
DCN	TLL1	ENSCAFP00000009230	ENSCAFP00000051087	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Metalloendopeptidase.	0.596
FURIN	TLL1	ENSCAFP00000065874	ENSCAFP00000051087	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Metalloendopeptidase.	0.591
IDE	MME	ENSCAFP00000011097	ENSCAFP00000064509	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Uncharacterized protein.	0.925
IDE	TLL1	ENSCAFP00000011097	ENSCAFP00000051087	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Metalloendopeptidase.	0.619
KEL	TLL1	ENSCAFP00000037116	ENSCAFP00000051087	Kell metallo-endopeptidase.	Metalloendopeptidase.	0.597
LNPEP	TLL1	ENSCAFP00000011519	ENSCAFP00000051087	Leucyl and cystinyl aminopeptidase.	Metalloendopeptidase.	0.562
MME	IDE	ENSCAFP00000064509	ENSCAFP00000011097	Uncharacterized protein.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.925
MME	TLL1	ENSCAFP00000064509	ENSCAFP00000051087	Uncharacterized protein.	Metalloendopeptidase.	0.584
OMA1	TLL1	ENSCAFP00000027897	ENSCAFP00000051087	OMA1 zinc metallopeptidase.	Metalloendopeptidase.	0.615
TLL1	CHRD	ENSCAFP00000051087	ENSCAFP00000041950	Metalloendopeptidase.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.719
TLL1	DCN	ENSCAFP00000051087	ENSCAFP00000009230	Metalloendopeptidase.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.596
TLL1	FURIN	ENSCAFP00000051087	ENSCAFP00000065874	Metalloendopeptidase.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.591
TLL1	IDE	ENSCAFP00000051087	ENSCAFP00000011097	Metalloendopeptidase.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.619
TLL1	KEL	ENSCAFP00000051087	ENSCAFP00000037116	Metalloendopeptidase.	Kell metallo-endopeptidase.	0.597
TLL1	LNPEP	ENSCAFP00000051087	ENSCAFP00000011519	Metalloendopeptidase.	Leucyl and cystinyl aminopeptidase.	0.562
TLL1	MME	ENSCAFP00000051087	ENSCAFP00000064509	Metalloendopeptidase.	Uncharacterized protein.	0.584
TLL1	OMA1	ENSCAFP00000051087	ENSCAFP00000027897	Metalloendopeptidase.	OMA1 zinc metallopeptidase.	0.615
TLL1	TRHDE	ENSCAFP00000051087	ENSCAFP00000000696	Metalloendopeptidase.	Thyrotropin releasing hormone degrading enzyme.	0.517
TLL1	TTC14	ENSCAFP00000051087	ENSCAFP00000016940	Metalloendopeptidase.	Tetratricopeptide repeat domain 14.	0.526