ZC2HC1C protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ZC2HC1C

Zinc finger C2HC-type containing 1C. (529 aa)

Predicted Functional Partners:

MEDAG

0.707

MLH3

0.699

RPS6KL1

0.679

PDGFRL

0.670

RBM25

0.656

SYNPO2

0.647

PAMR1

0.645

U2AF2

0.610

CDC5L

0.602

BMPER

0.572

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPER	MEDAG	ENSCAFP00000004726	ENSCAFP00000009838	BMP binding endothelial regulator.	Mesenteric estrogen dependent adipogenesis.	0.560
BMPER	PAMR1	ENSCAFP00000004726	ENSCAFP00000060491	BMP binding endothelial regulator.	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	0.460
BMPER	PDGFRL	ENSCAFP00000004726	ENSCAFP00000010340	BMP binding endothelial regulator.	Platelet derived growth factor receptor like.	0.525
BMPER	ZC2HC1C	ENSCAFP00000004726	ENSCAFP00000051167	BMP binding endothelial regulator.	Zinc finger C2HC-type containing 1C.	0.572
CDC5L	U2AF2	ENSCAFP00000002938	ENSCAFP00000003724	Cell division cycle 5 like.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.981
CDC5L	ZC2HC1C	ENSCAFP00000002938	ENSCAFP00000051167	Cell division cycle 5 like.	Zinc finger C2HC-type containing 1C.	0.602
MEDAG	BMPER	ENSCAFP00000009838	ENSCAFP00000004726	Mesenteric estrogen dependent adipogenesis.	BMP binding endothelial regulator.	0.560
MEDAG	PAMR1	ENSCAFP00000009838	ENSCAFP00000060491	Mesenteric estrogen dependent adipogenesis.	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	0.594
MEDAG	PDGFRL	ENSCAFP00000009838	ENSCAFP00000010340	Mesenteric estrogen dependent adipogenesis.	Platelet derived growth factor receptor like.	0.602
MEDAG	ZC2HC1C	ENSCAFP00000009838	ENSCAFP00000051167	Mesenteric estrogen dependent adipogenesis.	Zinc finger C2HC-type containing 1C.	0.707
MLH3	RPS6KL1	ENSCAFP00000066717	ENSCAFP00000054991	MutL homolog 3.	Ribosomal protein S6 kinase like 1.	0.675
MLH3	ZC2HC1C	ENSCAFP00000066717	ENSCAFP00000051167	MutL homolog 3.	Zinc finger C2HC-type containing 1C.	0.699
PAMR1	BMPER	ENSCAFP00000060491	ENSCAFP00000004726	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	BMP binding endothelial regulator.	0.460
PAMR1	MEDAG	ENSCAFP00000060491	ENSCAFP00000009838	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	Mesenteric estrogen dependent adipogenesis.	0.594
PAMR1	PDGFRL	ENSCAFP00000060491	ENSCAFP00000010340	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	Platelet derived growth factor receptor like.	0.567
PAMR1	ZC2HC1C	ENSCAFP00000060491	ENSCAFP00000051167	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	Zinc finger C2HC-type containing 1C.	0.645
PDGFRL	BMPER	ENSCAFP00000010340	ENSCAFP00000004726	Platelet derived growth factor receptor like.	BMP binding endothelial regulator.	0.525
PDGFRL	MEDAG	ENSCAFP00000010340	ENSCAFP00000009838	Platelet derived growth factor receptor like.	Mesenteric estrogen dependent adipogenesis.	0.602
PDGFRL	PAMR1	ENSCAFP00000010340	ENSCAFP00000060491	Platelet derived growth factor receptor like.	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	0.567
PDGFRL	ZC2HC1C	ENSCAFP00000010340	ENSCAFP00000051167	Platelet derived growth factor receptor like.	Zinc finger C2HC-type containing 1C.	0.670

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.714

expected number of edges:

25

PPI enrichment p-value:

0.0932

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

10 of 335

1.79

4.36

4.73e-14

GO:0006397

mRNA processing

10 of 420

1.69

3.84

2.19e-13

GO:0000398

mRNA splicing, via spliceosome

7 of 217

1.83

3.34

3.40e-09

GO:0051028

mRNA transport

4 of 90

1.97

2.11

4.38e-05

GO:0010467

Gene expression

11 of 1665

1.14

1.61

5.16e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1169

1.29

2.14

1.77e-11

GO:0003729

mRNA binding

4 of 282

1.47

1.06

0.0040

GO:0000339

RNA cap binding

2 of 16

2.41

1.01

0.0143

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 2

3.32

1.55

0.0016

GO:0016607

Nuclear speck

4 of 269

1.49

1.18

0.0019

GO:0002102

Podosome

2 of 18

2.36

1.16

0.0072

GO:0016604

Nuclear body

5 of 483

1.33

1.09

0.0016

GO:0005681

Spliceosomal complex

3 of 167

1.57

0.97

0.0089

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37941135

(2023) Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection.

2 of 15

2.44

0.89

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2649

RNA Polymerase II Transcription Termination, and mRNA Splicing - Major Pathway

11 of 130

2.25

8.36

1.64e-21

CL:2657

RNA recognition motif domain

8 of 71

2.37

6.63

5.76e-15

CL:2737

mRNA 3-end processing

4 of 22

2.58

3.37

4.30e-07

CL:2739

Mixed, incl. SRSF7, RNA recognition motif, and SRSF1, RNA recognition motif 1

3 of 13

2.68

2.46

2.89e-05

CL:2665

Mixed, incl. ROK, N-terminal, and TAF15/EWS/TLS family

3 of 13

2.68

2.46

2.89e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03040

Spliceosome

9 of 120

2.19

6.81

3.94e-17

pret03015

mRNA surveillance pathway

3 of 76

1.91

1.63

0.00050

pret05168

Herpes simplex virus 1 infection

4 of 268

1.49

1.37

0.00050

pret03013

RNA transport

3 of 136

1.66

1.31

0.0015

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 251

1.96

6.14

6.02e-19

MAP-72172

mRNA Splicing

11 of 272

1.92

5.93

7.14e-19

MAP-73856

RNA Polymerase II Transcription Termination

7 of 78

2.27

5.56

8.26e-13

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 362

1.8

5.04

1.04e-17

MAP-72187

mRNA 3-end processing

6 of 67

2.27

4.73

1.08e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 79

2.02

2.03

8.00e-05

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.14

1.64

0.0011

GOCC:0002102

Podosome

2 of 25

2.22

0.89

0.0225

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

8 of 325

1.71

3.4

9.87e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

8 of 233

1.85

3.77

1.54e-10

IPR035979

RNA-binding domain superfamily

8 of 257

1.81

3.65

1.66e-10

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

8 of 264

1.8

3.62

1.66e-10

IPR012987

ROK, N-terminal

2 of 2

3.32

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

8 of 227

1.86

4.08

1.38e-11

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