STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POLE2DNA polymerase epsilon 2, accessory subunit. (640 aa)    
Predicted Functional Partners:
POLE
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 0.999
POLE3
DNA polymerase epsilon 3, accessory subunit.
    
 0.994
POLE4
CBFD_NFYB_HMF domain-containing protein.
    
 0.991
MCM4
DNA helicase; Belongs to the MCM family.
   
 0.990
CDC45
Cell division cycle 45.
   
 0.990
MCM3
Minichromosome maintenance complex component 3; Belongs to the MCM family.
   
 0.987
MCM5
Minichromosome maintenance complex component 5; Belongs to the MCM family.
   
 0.987
MCM2
DNA helicase; Belongs to the MCM family.
   
 0.986
GINS1
GINS complex subunit 1.
   
 
 0.983
MCM6
DNA helicase; Belongs to the MCM family.
   
 0.981
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.