STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFAIP6TNF alpha induced protein 6. (296 aa)    
Predicted Functional Partners:
HAS2
Hyaluronan synthase 2.
   
  
 0.757
PTX3
Pentraxin 3.
   
 
 0.756
CXCL10
C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]
   
 
 0.664
CXCL11
C-X-C motif chemokine ligand 11.
   
 
 0.663
PTGS2
Prostaglandin-endoperoxide synthase 2.
   
  
 0.632
EREG
Epiregulin.
      
 0.614
HAS3
Hyaluronan synthase 3.
   
  
 0.596
HAS1
Hyaluronan synthase 1.
   
  
 0.590
INHBA
Inhibin subunit beta A.
   
 
 0.589
ADGRA2
Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.588
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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