NHLRC3 protein (Canis lupus familiaris) - STRING interaction network

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Score

NHLRC3

NHL repeat containing 3. (364 aa)

Predicted Functional Partners:

PROSER1

0.694

STOML3

0.482

FREM2

0.474

SMCHD1

0.433

SKAP2

0.424

GLB1

0.422

CYB5R3

0.400

ANXA2

0.400

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA2	CYB5R3	ENSCAFP00000049994	ENSCAFP00000039720	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.455
ANXA2	GLB1	ENSCAFP00000049994	ENSCAFP00000054350	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	0.418
ANXA2	NHLRC3	ENSCAFP00000049994	ENSCAFP00000051647	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	NHL repeat containing 3.	0.400
CYB5R3	ANXA2	ENSCAFP00000039720	ENSCAFP00000049994	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.455
CYB5R3	GLB1	ENSCAFP00000039720	ENSCAFP00000054350	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	0.425
CYB5R3	NHLRC3	ENSCAFP00000039720	ENSCAFP00000051647	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	NHL repeat containing 3.	0.400
FREM2	NHLRC3	ENSCAFP00000009013	ENSCAFP00000051647	FRAS1 related extracellular matrix 2.	NHL repeat containing 3.	0.474
FREM2	PROSER1	ENSCAFP00000009013	ENSCAFP00000008994	FRAS1 related extracellular matrix 2.	Proline and serine rich 1.	0.532
GLB1	ANXA2	ENSCAFP00000054350	ENSCAFP00000049994	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.418
GLB1	CYB5R3	ENSCAFP00000054350	ENSCAFP00000039720	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.425
GLB1	NHLRC3	ENSCAFP00000054350	ENSCAFP00000051647	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	NHL repeat containing 3.	0.422
NHLRC3	ANXA2	ENSCAFP00000051647	ENSCAFP00000049994	NHL repeat containing 3.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.400
NHLRC3	CYB5R3	ENSCAFP00000051647	ENSCAFP00000039720	NHL repeat containing 3.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.400
NHLRC3	FREM2	ENSCAFP00000051647	ENSCAFP00000009013	NHL repeat containing 3.	FRAS1 related extracellular matrix 2.	0.474
NHLRC3	GLB1	ENSCAFP00000051647	ENSCAFP00000054350	NHL repeat containing 3.	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family.	0.422
NHLRC3	PROSER1	ENSCAFP00000051647	ENSCAFP00000008994	NHL repeat containing 3.	Proline and serine rich 1.	0.694
NHLRC3	SKAP2	ENSCAFP00000051647	ENSCAFP00000004328	NHL repeat containing 3.	Src kinase associated phosphoprotein 2.	0.424
NHLRC3	SMCHD1	ENSCAFP00000051647	ENSCAFP00000058493	NHL repeat containing 3.	Structural maintenance of chromosomes flexible hinge domain containing 1.	0.433
NHLRC3	STOML3	ENSCAFP00000051647	ENSCAFP00000060743	NHL repeat containing 3.	Stomatin like 3.	0.482
PROSER1	FREM2	ENSCAFP00000008994	ENSCAFP00000009013	Proline and serine rich 1.	FRAS1 related extracellular matrix 2.	0.532