STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFSF12TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (420 aa)    
Predicted Functional Partners:
TNFRSF12A
Uncharacterized protein.
    
 0.972
TNFSF13
TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.
 
 
 
 0.954
TNFRSF13C
TNF receptor superfamily member 13C.
     
 0.845
PSMA8
Proteasome subunit alpha type.
   
 
 0.727
TNFSF13B
Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.
   
 0.714
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 
 0.685
TNFSF11
TNF superfamily member 11; Belongs to the tumor necrosis factor family.
     
 0.679
TNFSF14
Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family.
   
 
 0.668
IFI27L2
Uncharacterized protein.
      
 0.650
PRSS53
Serine protease 53; Belongs to the peptidase S1 family.
      
 0.648
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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