STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSTA4Glutathione S-transferase. (228 aa)    
Predicted Functional Partners:
SULT1D1
Sulfotransferase; Belongs to the sulfotransferase 1 family.
   
  
 0.715
GCLC
Glutamate-cysteine ligase catalytic subunit.
   
  
 0.573
GPX2
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
  
 0.561
GPX8
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
  
 0.557
GSTO1
Glutathione S-transferase omega 1; Belongs to the GST superfamily.
   
 
 0.556
GSTZ1
Glutathione S-transferase zeta 1; Belongs to the GST superfamily.
   
 
0.553
MCCC2
Methylcrotonoyl-CoA carboxylase 2.
   
  
 0.506
SULT1A1
Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
   
  
 0.504
TXNDC12
Thioredoxin domain containing 12.
   
 
 0.498
ALDH8A1
Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family.
   
 
 0.471
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.