Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP7B | NPC1 | ENSCAFP00000006351 | ENSCAFP00000057176 | ATPase copper transporting beta. | NPC intracellular cholesterol transporter 1. | 0.524 |
| ATP7B | NPC2-2 | ENSCAFP00000006351 | ENSCAFP00000052889 | ATPase copper transporting beta. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | 0.485 |
| CD52 | NPC2-2 | ENSCAFP00000018435 | ENSCAFP00000052889 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | 0.875 |
| CD52 | WFDC2 | ENSCAFP00000018435 | ENSCAFP00000014248 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | WAP four-disulfide core domain protein 2; Broad range protease inhibitor (By similarity). Possible function in sperm maturation. | 0.875 |
| CTSD | NPC1 | ENSCAFP00000014791 | ENSCAFP00000057176 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | NPC intracellular cholesterol transporter 1. | 0.491 |
| CTSD | NPC2-2 | ENSCAFP00000014791 | ENSCAFP00000052889 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | 0.490 |
| CTSD | SMPD1 | ENSCAFP00000014791 | ENSCAFP00000009604 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.460 |
| GM2A | NPC2-2 | ENSCAFP00000026432 | ENSCAFP00000052889 | GM2 ganglioside activator. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | 0.547 |
| NPC1 | ATP7B | ENSCAFP00000057176 | ENSCAFP00000006351 | NPC intracellular cholesterol transporter 1. | ATPase copper transporting beta. | 0.524 |
| NPC1 | CTSD | ENSCAFP00000057176 | ENSCAFP00000014791 | NPC intracellular cholesterol transporter 1. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.491 |
| NPC1 | NPC2-2 | ENSCAFP00000057176 | ENSCAFP00000052889 | NPC intracellular cholesterol transporter 1. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | 0.998 |
| NPC1 | SMPD1 | ENSCAFP00000057176 | ENSCAFP00000009604 | NPC intracellular cholesterol transporter 1. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.590 |
| NPC1 | STARD3 | ENSCAFP00000057176 | ENSCAFP00000024111 | NPC intracellular cholesterol transporter 1. | StAR related lipid transfer domain containing 3. | 0.642 |
| NPC2-2 | ATP7B | ENSCAFP00000052889 | ENSCAFP00000006351 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | ATPase copper transporting beta. | 0.485 |
| NPC2-2 | CD52 | ENSCAFP00000052889 | ENSCAFP00000018435 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | 0.875 |
| NPC2-2 | CTSD | ENSCAFP00000052889 | ENSCAFP00000014791 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.490 |
| NPC2-2 | GM2A | ENSCAFP00000052889 | ENSCAFP00000026432 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | GM2 ganglioside activator. | 0.547 |
| NPC2-2 | NPC1 | ENSCAFP00000052889 | ENSCAFP00000057176 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | NPC intracellular cholesterol transporter 1. | 0.998 |
| NPC2-2 | SCAP | ENSCAFP00000052889 | ENSCAFP00000019461 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | SREBF chaperone. | 0.626 |
| NPC2-2 | SMPD1 | ENSCAFP00000052889 | ENSCAFP00000009604 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.501 |
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