STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000053011UBIQUITIN_CONJUGAT_2 domain-containing protein. (111 aa)    
Predicted Functional Partners:
PRKN
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    
 
 0.792
CBL
Cbl proto-oncogene.
    
 
 0.754
WWP1
E3 ubiquitin-protein ligase.
    
 
 0.752
UBE3A
Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
   
 
 0.750
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
   
 
 0.748
ENSCAFP00000053186
annotation not available
   
 
 0.748
RNF213
Ring finger protein 213.
   
 
 0.741
RNF217
Ring finger protein 217.
   
 
 0.691
ENSCAFP00000047437
Uncharacterized protein.
   
 
 0.673
NEDD8
NEDD8 ubiquitin like modifier.
   
 
 0.655
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.