STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000053140Uncharacterized protein. (59 aa)    
Predicted Functional Partners:
MAPT
Microtubule-associated protein.
    
 
 0.760
CDK5R2
Cyclin-dependent kinase 5 activator.
    
 
 0.725
CDK5R1
Cyclin-dependent kinase 5 activator.
    
 
 0.725
FIBP
FGF1 intracellular binding protein.
   
 
 0.580
CABLES1
Cdk5 and Abl enzyme substrate 1.
    
 
 0.568
MAP2
Microtubule-associated protein.
    
 
 0.567
C2CD5
C2 calcium dependent domain containing 5.
    
 
 0.563
CDKN1B
Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
    
 
 0.548
CCNE1
Cyclin E1; Belongs to the cyclin family.
    
 
 0.544
CCNI2
Cyclin I family member 2; Belongs to the cyclin family.
    
 
 0.543
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.