STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000053346Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (184 aa)    
Predicted Functional Partners:
GIGYF2
GRB10 interacting GYF protein 2.
    
 
 0.737
LRCH4
GRB10 interacting GYF protein 1.
    
 
 0.648
EIF4EBP1
Eukaryotic translation initiation factor 4E binding protein 1.
    
 
 0.536
TARS1
Threonyl-tRNA synthetase.
   
 
 0.518
EIF5B
Eukaryotic translation initiation factor 5B.
      
 0.515
LIN7C
Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.
      
 0.463
SLC25A23
Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.457
EIF4ENIF1
Eukaryotic translation initiation factor 4E nuclear import factor 1.
   
 
 0.442
EIF3H
Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]
   
 
 0.428
NSFL1C
NSFL1 cofactor.
   
   0.423
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.