VWF protein (Canis lupus familiaris) - STRING interaction network

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VWF

Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (3256 aa)

Predicted Functional Partners:

ADAMTS13

0.997

F8

0.994

ITGA2B

0.982

ITGB3

0.979

GP1BB

0.960

ITGAV

0.919

ITGA6

0.912

ITGB2

0.911

CD34

0.909

ITGB8

0.905

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS13	F8	ENSCAFP00000029268	ENSCAFP00000029035	ADAM metallopeptidase with thrombospondin type 1 motif 13.	Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.	0.816
ADAMTS13	VWF	ENSCAFP00000029268	ENSCAFP00000053390	ADAM metallopeptidase with thrombospondin type 1 motif 13.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.997
CD34	ITGA2B	ENSCAFP00000017250	ENSCAFP00000053835	Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.618
CD34	ITGA6	ENSCAFP00000017250	ENSCAFP00000054417	Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.503
CD34	ITGB3	ENSCAFP00000017250	ENSCAFP00000032511	Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.454
CD34	VWF	ENSCAFP00000017250	ENSCAFP00000053390	Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.909
F8	ADAMTS13	ENSCAFP00000029035	ENSCAFP00000029268	Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.	ADAM metallopeptidase with thrombospondin type 1 motif 13.	0.816
F8	ITGA2B	ENSCAFP00000029035	ENSCAFP00000053835	Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.424
F8	VWF	ENSCAFP00000029035	ENSCAFP00000053390	Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.994
GP1BB	ITGA2B	ENSCAFP00000036500	ENSCAFP00000053835	Glycoprotein Ib platelet subunit beta.	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.647
GP1BB	ITGB3	ENSCAFP00000036500	ENSCAFP00000032511	Glycoprotein Ib platelet subunit beta.	Integrin beta; Belongs to the integrin beta chain family.	0.402
GP1BB	VWF	ENSCAFP00000036500	ENSCAFP00000053390	Glycoprotein Ib platelet subunit beta.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.960
ITGA2B	CD34	ENSCAFP00000053835	ENSCAFP00000017250	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).	0.618
ITGA2B	F8	ENSCAFP00000053835	ENSCAFP00000029035	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.	0.424
ITGA2B	GP1BB	ENSCAFP00000053835	ENSCAFP00000036500	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Glycoprotein Ib platelet subunit beta.	0.647
ITGA2B	ITGA6	ENSCAFP00000053835	ENSCAFP00000054417	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.862
ITGA2B	ITGAV	ENSCAFP00000053835	ENSCAFP00000050990	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.925
ITGA2B	ITGB2	ENSCAFP00000053835	ENSCAFP00000059524	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin beta.	0.909
ITGA2B	ITGB3	ENSCAFP00000053835	ENSCAFP00000032511	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999
ITGA2B	ITGB8	ENSCAFP00000053835	ENSCAFP00000058857	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.935

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