ATP10B protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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ATP10B

Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1521 aa)

Predicted Functional Partners:

LOC487951

0.678

TMEM30A

0.677

TMPRSS11D

0.605

ABCA12

0.590

TMPRSS4

0.575

CXCL17

0.574

CNNM3-2

0.516

KRT84

0.495

IL20RB

0.461

TMPRSS11E

0.454

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	ATP10B	ENSCAFP00000061269	ENSCAFP00000053712	ATP binding cassette subfamily A member 12.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.590
ATP10B	ABCA12	ENSCAFP00000053712	ENSCAFP00000061269	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	ATP binding cassette subfamily A member 12.	0.590
ATP10B	CNNM3-2	ENSCAFP00000053712	ENSCAFP00000003492	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Cyclin and CBS domain divalent metal cation transport mediator 3.	0.516
ATP10B	CXCL17	ENSCAFP00000053712	ENSCAFP00000007185	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	C-X-C motif chemokine ligand 17.	0.574
ATP10B	IL20RB	ENSCAFP00000053712	ENSCAFP00000011088	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Interleukin 20 receptor subunit beta.	0.461
ATP10B	KRT84	ENSCAFP00000053712	ENSCAFP00000010801	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Keratin 84; Belongs to the intermediate filament family.	0.495
ATP10B	LOC487951	ENSCAFP00000053712	ENSCAFP00000062958	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Cell cycle control protein; Belongs to the CDC50/LEM3 family.	0.678
ATP10B	TMEM30A	ENSCAFP00000053712	ENSCAFP00000003965	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Cell cycle control protein; Belongs to the CDC50/LEM3 family.	0.677
ATP10B	TMPRSS11D	ENSCAFP00000053712	ENSCAFP00000004128	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.605
ATP10B	TMPRSS11E	ENSCAFP00000053712	ENSCAFP00000043540	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Transmembrane serine protease 11E; Belongs to the peptidase S1 family.	0.454
ATP10B	TMPRSS4	ENSCAFP00000053712	ENSCAFP00000058627	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Transmembrane serine protease 4; Belongs to the peptidase S1 family.	0.575
CNNM3-2	ATP10B	ENSCAFP00000003492	ENSCAFP00000053712	Cyclin and CBS domain divalent metal cation transport mediator 3.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.516
CXCL17	ATP10B	ENSCAFP00000007185	ENSCAFP00000053712	C-X-C motif chemokine ligand 17.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.574
CXCL17	IL20RB	ENSCAFP00000007185	ENSCAFP00000011088	C-X-C motif chemokine ligand 17.	Interleukin 20 receptor subunit beta.	0.440
IL20RB	ATP10B	ENSCAFP00000011088	ENSCAFP00000053712	Interleukin 20 receptor subunit beta.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.461
IL20RB	CXCL17	ENSCAFP00000011088	ENSCAFP00000007185	Interleukin 20 receptor subunit beta.	C-X-C motif chemokine ligand 17.	0.440
IL20RB	TMPRSS11E	ENSCAFP00000011088	ENSCAFP00000043540	Interleukin 20 receptor subunit beta.	Transmembrane serine protease 11E; Belongs to the peptidase S1 family.	0.416
KRT84	ATP10B	ENSCAFP00000010801	ENSCAFP00000053712	Keratin 84; Belongs to the intermediate filament family.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.495
LOC487951	ATP10B	ENSCAFP00000062958	ENSCAFP00000053712	Cell cycle control protein; Belongs to the CDC50/LEM3 family.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.678
TMEM30A	ATP10B	ENSCAFP00000003965	ENSCAFP00000053712	Cell cycle control protein; Belongs to the CDC50/LEM3 family.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.677

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

0.132

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

7 of 96

1.41

1.81

2.98e-06

GO:0006281

DNA repair

5 of 43

1.61

1.75

6.67e-05

GO:0006310

DNA recombination

4 of 29

1.69

1.66

0.00019

GO:0006260

DNA replication

4 of 32

1.64

1.61

0.00021

GO:0071103

DNA conformation change

3 of 13

1.91

1.52

0.00087

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003697

Single-stranded DNA binding

3 of 6

2.25

1.73

0.00052

GO:0140097

Catalytic activity, acting on DNA

5 of 50

1.55

1.57

0.00015

GO:0003917

DNA topoisomerase type I (single strand cut, ATP-independent) activity

2 of 2

2.55

1.15

0.0080

GO:0003677

DNA binding

6 of 339

0.79

0.52

0.0155

GO:0003676

Nucleic acid binding

7 of 468

0.72

0.49

0.0122

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 21

1.7

1.13

0.0046

GO:0009295

Nucleoid

3 of 33

1.51

0.97

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:604

ATP-dependent activity, acting on DNA, and DNA/RNA polymerase superfamily

4 of 5

2.45

3.07

1.33e-06

CL:600

DNA replication, and SOS response

6 of 38

1.75

2.54

5.87e-07

CL:1721

Mixed, incl. Phasin, and Thioredoxin

2 of 6

2.07

0.81

0.0301

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka03440

Homologous recombination

4 of 18

1.89

2.14

2.76e-05

aka03030

DNA replication

3 of 15

1.85

1.52

0.00075

aka03430

Mismatch repair

2 of 12

1.77

0.83

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009295

Nucleoid

3 of 15

1.85

1.22

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 19

1.75

1.13

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00436

Single-strand binding protein family

2 of 2

2.55

0.9

0.0226

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