STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)    
Predicted Functional Partners:
TTC14
Tetratricopeptide repeat domain 14.
   
  
 0.763
MCCC1
Methylcrotonoyl-CoA carboxylase 1.
      
 0.653
DNAJC19
DnaJ heat shock protein family (Hsp40) member C19.
      
 0.650
MUC1
Mucin 1, cell surface associated.
      
 0.589
CDH17
Cadherin 17.
   
  
 0.565
PDCD4
Programmed cell death 4.
      
 0.553
MUC13
Mucin 13, cell surface associated.
      
 0.535
LGALS2
Galectin.
   
  
 0.530
TFF2
Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
   
  
 0.504
SFTPC
Pulmonary surfactant-associated protein C.
   
  
 0.475
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.