STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMP21Matrix metallopeptidase 21. (658 aa)    
Predicted Functional Partners:
LRFN2
Leucine rich repeat and fibronectin type III domain containing 2.
    
 
 0.677
FAT2
FAT atypical cadherin 2.
   
  
 0.600
SMC6
Structural maintenance of chromosomes 6.
      
 0.561
TIMP2
Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.
   
 
 0.521
DRC7
Dynein regulatory complex subunit 7.
      
 0.514
LLGL2
LLGL scribble cell polarity complex component 2.
      
 0.487
CCDC63
Coiled-coil domain containing 63.
      
 0.485
FOXA3
Forkhead box A3.
      
 0.483
FAT4
FAT atypical cadherin 4.
    
 
 0.466
TIMP3
TIMP metallopeptidase inhibitor 3.
   
 
 0.459
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.