STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRB2Crumbs cell polarity complex component 2. (1285 aa)    
Predicted Functional Partners:
CRB1
Crumbs cell polarity complex component 1.
   
0.914
CRB3
Crumbs cell polarity complex component 3.
      
 0.860
MPP5
MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebell [...]
    
 
 0.821
PATJ
PATJ crumbs cell polarity complex component.
   
 
 0.802
POGLUT1
Protein O-glucosyltransferase 1.
    
 
 0.652
AJUBA
Ajuba LIM protein.
    
 
 0.569
IMPG1
Interphotoreceptor matrix proteoglycan 1.
      
 0.567
LLGL2
LLGL scribble cell polarity complex component 2.
    
 
 0.561
RNF168
Ring finger protein 168.
      
 0.537
FRMD1
Uncharacterized protein.
   
 
 0.528
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.