PRKACA protein (Canis lupus familiaris) - STRING interaction network

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PRKACA

cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)

Predicted Functional Partners:

PRKAR1B

0.999

PRKAR2B

0.996

PRKAR2A

0.995

RYR2

0.988

PRKACB

0.987

PRKAR1A

0.987

CALML5

0.983

PKIA

0.980

CALML6

0.980

CREB1

0.977

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML5	CALML6	ENSCAFP00000007824	ENSCAFP00000028340	Calmodulin like 5.	Calmodulin like 6.	0.735
CALML5	PRKACA	ENSCAFP00000007824	ENSCAFP00000053880	Calmodulin like 5.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.983
CALML5	PRKACB	ENSCAFP00000007824	ENSCAFP00000030135	Calmodulin like 5.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.983
CALML5	RYR2	ENSCAFP00000007824	ENSCAFP00000014764	Calmodulin like 5.	Ryanodine receptor 2.	0.978
CALML6	CALML5	ENSCAFP00000028340	ENSCAFP00000007824	Calmodulin like 6.	Calmodulin like 5.	0.735
CALML6	CREB1	ENSCAFP00000028340	ENSCAFP00000019912	Calmodulin like 6.	cAMP responsive element binding protein 1.	0.522
CALML6	PRKACA	ENSCAFP00000028340	ENSCAFP00000053880	Calmodulin like 6.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.980
CALML6	PRKACB	ENSCAFP00000028340	ENSCAFP00000030135	Calmodulin like 6.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.979
CALML6	RYR2	ENSCAFP00000028340	ENSCAFP00000014764	Calmodulin like 6.	Ryanodine receptor 2.	0.977
CREB1	CALML6	ENSCAFP00000019912	ENSCAFP00000028340	cAMP responsive element binding protein 1.	Calmodulin like 6.	0.522
CREB1	PRKACA	ENSCAFP00000019912	ENSCAFP00000053880	cAMP responsive element binding protein 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.977
CREB1	PRKACB	ENSCAFP00000019912	ENSCAFP00000030135	cAMP responsive element binding protein 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.976
CREB1	PRKAR1A	ENSCAFP00000019912	ENSCAFP00000047963	cAMP responsive element binding protein 1.	Protein kinase cAMP-dependent type I regulatory subunit alpha.	0.549
CREB1	PRKAR2B	ENSCAFP00000019912	ENSCAFP00000060895	cAMP responsive element binding protein 1.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.436
PKIA	PRKACA	ENSCAFP00000012265	ENSCAFP00000053880	cAMP-dependent protein kinase inhibitor alpha.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.980
PKIA	PRKACB	ENSCAFP00000012265	ENSCAFP00000030135	cAMP-dependent protein kinase inhibitor alpha.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.979
PRKACA	CALML5	ENSCAFP00000053880	ENSCAFP00000007824	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Calmodulin like 5.	0.983
PRKACA	CALML6	ENSCAFP00000053880	ENSCAFP00000028340	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Calmodulin like 6.	0.980
PRKACA	CREB1	ENSCAFP00000053880	ENSCAFP00000019912	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	cAMP responsive element binding protein 1.	0.977
PRKACA	PKIA	ENSCAFP00000053880	ENSCAFP00000012265	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	cAMP-dependent protein kinase inhibitor alpha.	0.980

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