STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TBCKTBC1 domain containing kinase. (896 aa)    
Predicted Functional Partners:
NME6
Nucleoside diphosphate kinase.
   
  
 0.815
CNPY2
Saposin B-type domain-containing protein.
      
 0.773
SH3BGRL3
SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family.
      
 0.678
POLR2E
RNA polymerase II subunit E.
      
 0.662
PDAP1
PDGFA associated protein 1.
      
 0.612
CLN3
Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.
      
 0.604
CLN5
Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family.
   
  
 0.587
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
   
  
 0.571
SELENOF
Sep15_SelM domain-containing protein.
      
 0.565
UBE2F
Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family.
      
 0.563
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.