STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMC6Structural maintenance of chromosomes 6. (1156 aa)    
Predicted Functional Partners:
SMC5
Structural maintenance of chromosomes 5.
   
 
0.990
NSMCE4A
Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
   
 
 0.989
NSMCE2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
    
 
 0.977
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
    
 
 0.976
SMC3
Structural maintenance of chromosomes protein.
   
 
 0.882
SMC4
Structural maintenance of chromosomes protein.
   
  
 0.868
STAG3
Stromal antigen 3.
   
 
 0.846
PAXIP1
PAX interacting protein 1.
   
 
 0.838
MDC1
Mediator of DNA damage checkpoint 1.
   
 
 0.837
NCAPG
Non-SMC condensin I complex subunit G.
   
 
 0.784
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.