STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CEP57Centrosomal protein 57. (694 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
   
 
 0.833
CEP63
Centrosomal protein 63.
   
 
 0.748
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B.
   
  
 0.734
CEP290
Centrosomal protein 290.
   
 
 0.718
CEP135
Centrosomal protein 135.
   
 
 0.697
ALMS1
ALMS1 centrosome and basal body associated protein.
   
  
 0.676
PLK4
Polo like kinase 4.
   
  
 0.605
CEP164
Centrosomal protein 164.
      
 0.602
TRIP13
Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...]
   
  
 0.567
POC1B
POC1 centriolar protein B.
      
 0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.