ENSCAFP00000055086 protein (Canis lupus familiaris)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSCAFP00000055086

Uncharacterized protein. (170 aa)

Predicted Functional Partners:

TMEM214

0.675

TMEM68

0.668

AMZ2

0.566

PHACTR3

0.564

GTF2F2

0.560

CGNL1

0.515

SH2B2

0.515

OPALIN

0.510

ATP6V1H

0.480

NDUFA9

0.480

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMZ2	ENSCAFP00000055086	ENSCAFP00000016352	ENSCAFP00000055086	Archaelysin family metallopeptidase 2.	Uncharacterized protein.	0.566
AMZ2	GTF2F2	ENSCAFP00000016352	ENSCAFP00000006776	Archaelysin family metallopeptidase 2.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.515
AMZ2	NDUFA9	ENSCAFP00000016352	ENSCAFP00000061074	Archaelysin family metallopeptidase 2.	NADH:ubiquinone oxidoreductase subunit A9.	0.400
AMZ2	OPALIN	ENSCAFP00000016352	ENSCAFP00000040714	Archaelysin family metallopeptidase 2.	Oligodendrocytic myelin paranodal and inner loop protein.	0.412
AMZ2	PHACTR3	ENSCAFP00000016352	ENSCAFP00000032113	Archaelysin family metallopeptidase 2.	Phosphatase and actin regulator.	0.515
AMZ2	SH2B2	ENSCAFP00000016352	ENSCAFP00000042944	Archaelysin family metallopeptidase 2.	SH2B adaptor protein 2.	0.479
AMZ2	TMEM214	ENSCAFP00000016352	ENSCAFP00000006928	Archaelysin family metallopeptidase 2.	Transmembrane protein 214.	0.561
ATP6V1H	ENSCAFP00000055086	ENSCAFP00000056653	ENSCAFP00000055086	ATPase H+ transporting V1 subunit H.	Uncharacterized protein.	0.480
ATP6V1H	TMEM214	ENSCAFP00000056653	ENSCAFP00000006928	ATPase H+ transporting V1 subunit H.	Transmembrane protein 214.	0.407
CGNL1	ENSCAFP00000055086	ENSCAFP00000023957	ENSCAFP00000055086	Cingulin like 1.	Uncharacterized protein.	0.515
CGNL1	TMEM68	ENSCAFP00000023957	ENSCAFP00000010394	Cingulin like 1.	Transmembrane protein 68.	0.515
ENSCAFP00000055086	AMZ2	ENSCAFP00000055086	ENSCAFP00000016352	Uncharacterized protein.	Archaelysin family metallopeptidase 2.	0.566
ENSCAFP00000055086	ATP6V1H	ENSCAFP00000055086	ENSCAFP00000056653	Uncharacterized protein.	ATPase H+ transporting V1 subunit H.	0.480
ENSCAFP00000055086	CGNL1	ENSCAFP00000055086	ENSCAFP00000023957	Uncharacterized protein.	Cingulin like 1.	0.515
ENSCAFP00000055086	GTF2F2	ENSCAFP00000055086	ENSCAFP00000006776	Uncharacterized protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.560
ENSCAFP00000055086	NDUFA9	ENSCAFP00000055086	ENSCAFP00000061074	Uncharacterized protein.	NADH:ubiquinone oxidoreductase subunit A9.	0.480
ENSCAFP00000055086	OPALIN	ENSCAFP00000055086	ENSCAFP00000040714	Uncharacterized protein.	Oligodendrocytic myelin paranodal and inner loop protein.	0.510
ENSCAFP00000055086	PHACTR3	ENSCAFP00000055086	ENSCAFP00000032113	Uncharacterized protein.	Phosphatase and actin regulator.	0.564
ENSCAFP00000055086	SH2B2	ENSCAFP00000055086	ENSCAFP00000042944	Uncharacterized protein.	SH2B adaptor protein 2.	0.515
ENSCAFP00000055086	TMEM214	ENSCAFP00000055086	ENSCAFP00000006928	Uncharacterized protein.	Transmembrane protein 214.	0.675

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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