STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC35F6Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (402 aa)    
Predicted Functional Partners:
FAF2
Fas associated factor family member 2.
   
  
 0.627
OTUD4
OTU deubiquitinase 4.
   
  
 0.565
UBQLN4
Ubiquilin 4.
    
 
 0.539
NTRK1
Tyrosine-protein kinase receptor.
    
 
 0.517
ADSS2
Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
  
  
 0.516
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
      
 0.515
LOC606974
Uncharacterized protein.
   
  
 0.512
LOC491239
Uncharacterized protein.
   
  
 0.512
HDAC5
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
  
 0.487
ESD
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
   
  
 0.485
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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