ENSCAFP00000055739 protein (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSCAFP00000055739

BcrAD_BadFG domain-containing protein. (281 aa)

Predicted Functional Partners:

AMDHD2

0.809

GNPDA1

0.624

H6PD

0.617

GNPDA2

0.550

CDK18

0.531

PGLS

0.523

NUCKS1

0.515

CPE

0.515

ZNF646

0.514

CCDC93

0.511

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMDHD2	ENSCAFP00000055739	ENSCAFP00000046060	ENSCAFP00000055739	Amidohydro-rel domain-containing protein.	BcrAD_BadFG domain-containing protein.	0.809
AMDHD2	GNPDA1	ENSCAFP00000046060	ENSCAFP00000053266	Amidohydro-rel domain-containing protein.	Glucosamine-6-phosphate isomerase.	0.984
AMDHD2	GNPDA2	ENSCAFP00000046060	ENSCAFP00000053528	Amidohydro-rel domain-containing protein.	Glucosamine-6-phosphate deaminase 2.	0.984
AMDHD2	H6PD	ENSCAFP00000046060	ENSCAFP00000053617	Amidohydro-rel domain-containing protein.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.961
AMDHD2	PGLS	ENSCAFP00000046060	ENSCAFP00000022506	Amidohydro-rel domain-containing protein.	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	0.937
CCDC93	ENSCAFP00000055739	ENSCAFP00000046164	ENSCAFP00000055739	Coiled-coil domain containing 93.	BcrAD_BadFG domain-containing protein.	0.511
CCDC93	ZNF646	ENSCAFP00000046164	ENSCAFP00000024690	Coiled-coil domain containing 93.	Zinc finger protein 646.	0.563
CDK18	ENSCAFP00000055739	ENSCAFP00000014825	ENSCAFP00000055739	Cyclin dependent kinase 18; Belongs to the protein kinase superfamily.	BcrAD_BadFG domain-containing protein.	0.531
CDK18	NUCKS1	ENSCAFP00000014825	ENSCAFP00000014936	Cyclin dependent kinase 18; Belongs to the protein kinase superfamily.	Nuclear casein kinase and cyclin dependent kinase substrate 1.	0.537
CPE	ENSCAFP00000055739	ENSCAFP00000038232	ENSCAFP00000055739	Carboxypeptidase E.	BcrAD_BadFG domain-containing protein.	0.515
ENSCAFP00000055739	AMDHD2	ENSCAFP00000055739	ENSCAFP00000046060	BcrAD_BadFG domain-containing protein.	Amidohydro-rel domain-containing protein.	0.809
ENSCAFP00000055739	CCDC93	ENSCAFP00000055739	ENSCAFP00000046164	BcrAD_BadFG domain-containing protein.	Coiled-coil domain containing 93.	0.511
ENSCAFP00000055739	CDK18	ENSCAFP00000055739	ENSCAFP00000014825	BcrAD_BadFG domain-containing protein.	Cyclin dependent kinase 18; Belongs to the protein kinase superfamily.	0.531
ENSCAFP00000055739	CPE	ENSCAFP00000055739	ENSCAFP00000038232	BcrAD_BadFG domain-containing protein.	Carboxypeptidase E.	0.515
ENSCAFP00000055739	GNPDA1	ENSCAFP00000055739	ENSCAFP00000053266	BcrAD_BadFG domain-containing protein.	Glucosamine-6-phosphate isomerase.	0.624
ENSCAFP00000055739	GNPDA2	ENSCAFP00000055739	ENSCAFP00000053528	BcrAD_BadFG domain-containing protein.	Glucosamine-6-phosphate deaminase 2.	0.550
ENSCAFP00000055739	H6PD	ENSCAFP00000055739	ENSCAFP00000053617	BcrAD_BadFG domain-containing protein.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.617
ENSCAFP00000055739	NUCKS1	ENSCAFP00000055739	ENSCAFP00000014936	BcrAD_BadFG domain-containing protein.	Nuclear casein kinase and cyclin dependent kinase substrate 1.	0.515
ENSCAFP00000055739	PGLS	ENSCAFP00000055739	ENSCAFP00000022506	BcrAD_BadFG domain-containing protein.	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	0.523
ENSCAFP00000055739	ZNF646	ENSCAFP00000055739	ENSCAFP00000024690	BcrAD_BadFG domain-containing protein.	Zinc finger protein 646.	0.514

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About