STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENPP6Ectonucleotide pyrophosphatase/phosphodiesterase 6. (483 aa)    
Predicted Functional Partners:
OPALIN
Oligodendrocytic myelin paranodal and inner loop protein.
   
  
 0.700
FBXL15
F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family.
   
  
 0.688
MYRF
Myelin regulatory factor.
      
 0.687
FBXW2
F-box and WD repeat domain containing 2.
   
  
 0.672
SOX10
SRY-box transcription factor 10.
   
 
 0.635
HCCS
Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
      
 0.559
TMEM86B
Transmembrane protein 86B.
   
  
 0.519
BCAS1
Breast carcinoma amplified sequence 1.
   
  
 0.516
OLIG2
Oligodendrocyte transcription factor 2.
      
 0.515
APBA3
Amyloid beta precursor protein binding family A member 3.
   
  
 0.498
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.