STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AP4S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)    
Predicted Functional Partners:
AP4E1
Adaptor related protein complex 4 subunit epsilon 1.
    
 0.999
AP4M1
AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and [...]
    
 
 0.999
AP4B1
AP complex subunit beta; Belongs to the adaptor complexes large subunit family.
    
 0.997
RUSC2
RUN and SH3 domain containing 2.
   
  
 0.947
TEPSIN
TEPSIN adaptor related protein complex 4 accessory protein.
    
 
 0.880
SERINC1
Serine incorporator 1.
      
 0.846
ATG9A
Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.
      
 0.783
RUSC1
RUN and SH3 domain containing 1.
   
  
 0.780
AP5M1
Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family.
    
 
 0.768
AP2B1
AP complex subunit beta.
    
 
 0.761
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.