ENSCAFP00000056380 protein (Canis lupus familiaris)

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ENSCAFP00000056380

THF_DHG_CYH domain-containing protein. (110 aa)

Predicted Functional Partners:

LOC100856570

0.974

LOC487740

0.974

FPGS

0.860

SHMT1

0.831

SHMT2

0.824

FTCD

0.809

PPAT

0.722

MTHFD2L

0.714

MTHFD2

0.712

GLDC

0.702

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000056380	FPGS	ENSCAFP00000056380	ENSCAFP00000029808	THF_DHG_CYH domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.860
ENSCAFP00000056380	FTCD	ENSCAFP00000056380	ENSCAFP00000017558	THF_DHG_CYH domain-containing protein.	Formimidoyltransferase cyclodeaminase.	0.809
ENSCAFP00000056380	GLDC	ENSCAFP00000056380	ENSCAFP00000051226	THF_DHG_CYH domain-containing protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.702
ENSCAFP00000056380	LOC100856570	ENSCAFP00000056380	ENSCAFP00000013625	THF_DHG_CYH domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.974
ENSCAFP00000056380	LOC487740	ENSCAFP00000056380	ENSCAFP00000036914	THF_DHG_CYH domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.974
ENSCAFP00000056380	MTHFD2	ENSCAFP00000056380	ENSCAFP00000012812	THF_DHG_CYH domain-containing protein.	Uncharacterized protein.	0.712
ENSCAFP00000056380	MTHFD2L	ENSCAFP00000056380	ENSCAFP00000059857	THF_DHG_CYH domain-containing protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.714
ENSCAFP00000056380	PPAT	ENSCAFP00000056380	ENSCAFP00000003241	THF_DHG_CYH domain-containing protein.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.722
ENSCAFP00000056380	SHMT1	ENSCAFP00000056380	ENSCAFP00000026966	THF_DHG_CYH domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.831
ENSCAFP00000056380	SHMT2	ENSCAFP00000056380	ENSCAFP00000000282	THF_DHG_CYH domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.824
FPGS	ENSCAFP00000056380	ENSCAFP00000029808	ENSCAFP00000056380	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	THF_DHG_CYH domain-containing protein.	0.860
FPGS	GLDC	ENSCAFP00000029808	ENSCAFP00000051226	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.463
FPGS	LOC100856570	ENSCAFP00000029808	ENSCAFP00000013625	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.556
FPGS	LOC487740	ENSCAFP00000029808	ENSCAFP00000036914	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.556
FPGS	MTHFD2	ENSCAFP00000029808	ENSCAFP00000012812	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Uncharacterized protein.	0.863
FPGS	MTHFD2L	ENSCAFP00000029808	ENSCAFP00000059857	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.862
FPGS	PPAT	ENSCAFP00000029808	ENSCAFP00000003241	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.685
FPGS	SHMT1	ENSCAFP00000029808	ENSCAFP00000026966	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.909
FPGS	SHMT2	ENSCAFP00000029808	ENSCAFP00000000282	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.909
FTCD	ENSCAFP00000056380	ENSCAFP00000017558	ENSCAFP00000056380	Formimidoyltransferase cyclodeaminase.	THF_DHG_CYH domain-containing protein.	0.809