| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASL | CES1 | ENSCAFP00000014967 | ENSCAFP00000056757 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | 0.836 |
| ASL | CES2 | ENSCAFP00000014967 | ENSCAFP00000053229 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.836 |
| ASL | UGT1A6 | ENSCAFP00000014967 | ENSCAFP00000064520 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.916 |
| CDA | CES1 | ENSCAFP00000022181 | ENSCAFP00000056757 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | 0.806 |
| CDA | CES2 | ENSCAFP00000022181 | ENSCAFP00000053229 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.845 |
| CES1 | ASL | ENSCAFP00000056757 | ENSCAFP00000014967 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.836 |
| CES1 | CDA | ENSCAFP00000056757 | ENSCAFP00000022181 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.806 |
| CES1 | CES2 | ENSCAFP00000056757 | ENSCAFP00000053229 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.838 |
| CES1 | CTSA | ENSCAFP00000056757 | ENSCAFP00000014432 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.862 |
| CES1 | CYP2C18 | ENSCAFP00000056757 | ENSCAFP00000011937 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Cytochrome P450 2C21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. | 0.845 |
| CES1 | EPX | ENSCAFP00000056757 | ENSCAFP00000053983 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Eosinophil peroxidase. | 0.731 |
| CES1 | GUK1 | ENSCAFP00000056757 | ENSCAFP00000057276 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Guanylate kinase 1. | 0.707 |
| CES1 | HINT1 | ENSCAFP00000056757 | ENSCAFP00000061085 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | HIT domain-containing protein. | 0.888 |
| CES1 | MPO | ENSCAFP00000056757 | ENSCAFP00000025760 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Myeloperoxidase. | 0.762 |
| CES1 | UGT1A6 | ENSCAFP00000056757 | ENSCAFP00000064520 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.828 |
| CES2 | ASL | ENSCAFP00000053229 | ENSCAFP00000014967 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.836 |
| CES2 | CDA | ENSCAFP00000053229 | ENSCAFP00000022181 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.845 |
| CES2 | CES1 | ENSCAFP00000053229 | ENSCAFP00000056757 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | 0.838 |
| CES2 | CYP2C18 | ENSCAFP00000053229 | ENSCAFP00000011937 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Cytochrome P450 2C21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. | 0.646 |
| CES2 | EPX | ENSCAFP00000053229 | ENSCAFP00000053983 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Eosinophil peroxidase. | 0.610 |
