ENSCAFP00000057067 protein (Canis lupus familiaris)

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Known Interactions

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Predicted Interactions

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ENSCAFP00000057067

Myotubularin phosphatase domain-containing protein. (544 aa)

Predicted Functional Partners:

LRGUK

0.539

MYO7B

0.525

MTMR2

0.489

ACOXL

0.480

ENPP3

0.474

HS6ST3

0.463

CHST11

0.459

UBAC2

0.404

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOXL	ENSCAFP00000057067	ENSCAFP00000052173	ENSCAFP00000057067	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Myotubularin phosphatase domain-containing protein.	0.480
ACOXL	HS6ST3	ENSCAFP00000052173	ENSCAFP00000059837	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	0.407
CHST11	ENSCAFP00000057067	ENSCAFP00000040518	ENSCAFP00000057067	Carbohydrate sulfotransferase.	Myotubularin phosphatase domain-containing protein.	0.459
ENPP3	ENSCAFP00000057067	ENSCAFP00000000528	ENSCAFP00000057067	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	Myotubularin phosphatase domain-containing protein.	0.474
ENSCAFP00000057067	ACOXL	ENSCAFP00000057067	ENSCAFP00000052173	Myotubularin phosphatase domain-containing protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.480
ENSCAFP00000057067	CHST11	ENSCAFP00000057067	ENSCAFP00000040518	Myotubularin phosphatase domain-containing protein.	Carbohydrate sulfotransferase.	0.459
ENSCAFP00000057067	ENPP3	ENSCAFP00000057067	ENSCAFP00000000528	Myotubularin phosphatase domain-containing protein.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.474
ENSCAFP00000057067	HS6ST3	ENSCAFP00000057067	ENSCAFP00000059837	Myotubularin phosphatase domain-containing protein.	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	0.463
ENSCAFP00000057067	LRGUK	ENSCAFP00000057067	ENSCAFP00000001870	Myotubularin phosphatase domain-containing protein.	Leucine rich repeats and guanylate kinase domain containing.	0.539
ENSCAFP00000057067	MTMR2	ENSCAFP00000057067	ENSCAFP00000043769	Myotubularin phosphatase domain-containing protein.	Myotubularin related protein 2.	0.489
ENSCAFP00000057067	MYO7B	ENSCAFP00000057067	ENSCAFP00000035971	Myotubularin phosphatase domain-containing protein.	Myosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.525
ENSCAFP00000057067	UBAC2	ENSCAFP00000057067	ENSCAFP00000062387	Myotubularin phosphatase domain-containing protein.	UBA domain containing 2.	0.404
HS6ST3	ACOXL	ENSCAFP00000059837	ENSCAFP00000052173	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.407
HS6ST3	ENSCAFP00000057067	ENSCAFP00000059837	ENSCAFP00000057067	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	Myotubularin phosphatase domain-containing protein.	0.463
LRGUK	ENSCAFP00000057067	ENSCAFP00000001870	ENSCAFP00000057067	Leucine rich repeats and guanylate kinase domain containing.	Myotubularin phosphatase domain-containing protein.	0.539
MTMR2	ENSCAFP00000057067	ENSCAFP00000043769	ENSCAFP00000057067	Myotubularin related protein 2.	Myotubularin phosphatase domain-containing protein.	0.489
MYO7B	ENSCAFP00000057067	ENSCAFP00000035971	ENSCAFP00000057067	Myosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myotubularin phosphatase domain-containing protein.	0.525
UBAC2	ENSCAFP00000057067	ENSCAFP00000062387	ENSCAFP00000057067	UBA domain containing 2.	Myotubularin phosphatase domain-containing protein.	0.404

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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