STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKR1A1Aldo_ket_red domain-containing protein. (325 aa)    
Predicted Functional Partners:
ALDH3B1
Aldehyde dehydrogenase 3 family member B1; Belongs to the aldehyde dehydrogenase family.
   
 0.941
ALDH3A1
Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
   
 0.936
CRYL1
Crystallin lambda 1.
   
 
 0.930
ALDH1B1
Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family.
   
 0.929
MAPKAPK5
MAPK activated protein kinase 5; Belongs to the aldehyde dehydrogenase family.
   
 0.929
ALDH16A1
Aldehyde dehydrogenase 16 family member A1.
   
 0.925
ALDH7A1
Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.
   
 0.925
ALDH9A1
Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family.
   
 0.924
ADH4
Alcohol dehydrogenase 4 (class II), pi polypeptide.
   
 0.919
ASL
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
   
 
 0.915
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.