STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM22ADAM metallopeptidase domain 22. (970 aa)    
Predicted Functional Partners:
LGI4
Leucine rich repeat LGI family member 4.
   
 
 0.969
LGI2
Leucine rich repeat LGI family member 2.
   
 
 0.955
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
   
 0.901
LGI3
Leucine rich repeat LGI family member 3.
   
 
 0.879
LGI1
Leucine rich glioma inactivated 1.
   
 
 0.721
NFASC
Neurofascin.
      
 0.714
CACNG2
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
 
 0.682
TEX47
Testis expressed 47.
      
 0.645
ADGRG6
Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.611
NRG1
Neuregulin 1.
      
 0.600
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.