DEF8 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

DEF8

Differentially expressed in FDCP 8 homolog. (610 aa)

Predicted Functional Partners:

ZNF276

0.860

SPIRE2

0.816

DBNDD1

0.812

VPS9D1

0.811

PRSS36

0.790

MNS1

0.788

HIBADH

0.785

CHMP1A

0.722

CDK10

0.711

GAS8

0.697

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK10	CHMP1A	ENSCAFP00000029350	ENSCAFP00000032438	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Charged multivesicular body protein 1A.	0.580
CDK10	DBNDD1	ENSCAFP00000029350	ENSCAFP00000029322	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Dysbindin domain containing 1.	0.784
CDK10	DEF8	ENSCAFP00000029350	ENSCAFP00000057218	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Differentially expressed in FDCP 8 homolog.	0.711
CDK10	GAS8	ENSCAFP00000029350	ENSCAFP00000029319	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Growth arrest specific 8.	0.600
CDK10	HIBADH	ENSCAFP00000029350	ENSCAFP00000004423	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.670
CDK10	MNS1	ENSCAFP00000029350	ENSCAFP00000023646	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Meiosis specific nuclear structural 1.	0.682
CDK10	SPIRE2	ENSCAFP00000029350	ENSCAFP00000029335	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Spire type actin nucleation factor 2.	0.573
CDK10	VPS9D1	ENSCAFP00000029350	ENSCAFP00000029347	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	VPS9 domain containing 1.	0.782
CDK10	ZNF276	ENSCAFP00000029350	ENSCAFP00000056766	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	Zinc finger protein 276.	0.658
CHMP1A	CDK10	ENSCAFP00000032438	ENSCAFP00000029350	Charged multivesicular body protein 1A.	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	0.580
CHMP1A	DBNDD1	ENSCAFP00000032438	ENSCAFP00000029322	Charged multivesicular body protein 1A.	Dysbindin domain containing 1.	0.769
CHMP1A	DEF8	ENSCAFP00000032438	ENSCAFP00000057218	Charged multivesicular body protein 1A.	Differentially expressed in FDCP 8 homolog.	0.722
CHMP1A	GAS8	ENSCAFP00000032438	ENSCAFP00000029319	Charged multivesicular body protein 1A.	Growth arrest specific 8.	0.570
CHMP1A	HIBADH	ENSCAFP00000032438	ENSCAFP00000004423	Charged multivesicular body protein 1A.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.650
CHMP1A	MNS1	ENSCAFP00000032438	ENSCAFP00000023646	Charged multivesicular body protein 1A.	Meiosis specific nuclear structural 1.	0.676
CHMP1A	SPIRE2	ENSCAFP00000032438	ENSCAFP00000029335	Charged multivesicular body protein 1A.	Spire type actin nucleation factor 2.	0.575
CHMP1A	VPS9D1	ENSCAFP00000032438	ENSCAFP00000029347	Charged multivesicular body protein 1A.	VPS9 domain containing 1.	0.775
CHMP1A	ZNF276	ENSCAFP00000032438	ENSCAFP00000056766	Charged multivesicular body protein 1A.	Zinc finger protein 276.	0.673
DBNDD1	CDK10	ENSCAFP00000029322	ENSCAFP00000029350	Dysbindin domain containing 1.	Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.	0.784
DBNDD1	CHMP1A	ENSCAFP00000029322	ENSCAFP00000032438	Dysbindin domain containing 1.	Charged multivesicular body protein 1A.	0.769

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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