STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (740 aa)    
Predicted Functional Partners:
PAK3
P21 (RAC1) activated kinase 3.
   
 0.991
GIT1
GIT ArfGAP 1.
   
 0.975
PAK2
Non-specific serine/threonine protein kinase.
   
 0.970
PAK1
Non-specific serine/threonine protein kinase.
    
 0.963
PAK5
Non-specific serine/threonine protein kinase.
    
 0.944
ARHGEF1
DH domain-containing protein.
    
 0.940
PAK6
Non-specific serine/threonine protein kinase.
    
 0.939
RAC2
Rac family small GTPase 2.
   
 0.936
RAC3
Uncharacterized protein.
   
 0.936
PARVB
Parvin beta.
   
 0.927
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.