ENSCAFP00000058253 protein (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSCAFP00000058253

Uncharacterized protein. (160 aa)

Predicted Functional Partners:

FAU

0.950

ENSCAFP00000054759

0.950

ENSCAFP00000061156

0.950

RPS5

0.906

RPS18

0.902

RPL8

0.825

RPL15

0.825

RPL24

0.823

RPL19

0.823

F1PS88_CANLF

0.813

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000054759	ENSCAFP00000058253	ENSCAFP00000054759	ENSCAFP00000058253	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.950
ENSCAFP00000054759	ENSCAFP00000061156	ENSCAFP00000054759	ENSCAFP00000061156	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.913
ENSCAFP00000054759	F1PS88_CANLF	ENSCAFP00000054759	ENSCAFP00000015630	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family.	0.997
ENSCAFP00000054759	FAU	ENSCAFP00000054759	ENSCAFP00000033982	Ubiquitin-like domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.912
ENSCAFP00000054759	RPL15	ENSCAFP00000054759	ENSCAFP00000008630	Ubiquitin-like domain-containing protein.	60S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.998
ENSCAFP00000054759	RPL19	ENSCAFP00000054759	ENSCAFP00000024264	Ubiquitin-like domain-containing protein.	60S ribosomal protein L19.	0.999
ENSCAFP00000054759	RPL24	ENSCAFP00000054759	ENSCAFP00000014113	Ubiquitin-like domain-containing protein.	Ribosomal protein L24.	0.998
ENSCAFP00000054759	RPL8	ENSCAFP00000054759	ENSCAFP00000002440	Ubiquitin-like domain-containing protein.	Ribosomal protein L8.	0.997
ENSCAFP00000054759	RPS18	ENSCAFP00000054759	ENSCAFP00000061231	Ubiquitin-like domain-containing protein.	40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA; Belongs to the universal ribosomal protein uS13 family.	0.999
ENSCAFP00000054759	RPS5	ENSCAFP00000054759	ENSCAFP00000003434	Ubiquitin-like domain-containing protein.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.995
ENSCAFP00000058253	ENSCAFP00000054759	ENSCAFP00000058253	ENSCAFP00000054759	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.950
ENSCAFP00000058253	ENSCAFP00000061156	ENSCAFP00000058253	ENSCAFP00000061156	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.950
ENSCAFP00000058253	F1PS88_CANLF	ENSCAFP00000058253	ENSCAFP00000015630	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family.	0.813
ENSCAFP00000058253	FAU	ENSCAFP00000058253	ENSCAFP00000033982	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.950
ENSCAFP00000058253	RPL15	ENSCAFP00000058253	ENSCAFP00000008630	Uncharacterized protein.	60S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.825
ENSCAFP00000058253	RPL19	ENSCAFP00000058253	ENSCAFP00000024264	Uncharacterized protein.	60S ribosomal protein L19.	0.823
ENSCAFP00000058253	RPL24	ENSCAFP00000058253	ENSCAFP00000014113	Uncharacterized protein.	Ribosomal protein L24.	0.823
ENSCAFP00000058253	RPL8	ENSCAFP00000058253	ENSCAFP00000002440	Uncharacterized protein.	Ribosomal protein L8.	0.825
ENSCAFP00000058253	RPS18	ENSCAFP00000058253	ENSCAFP00000061231	Uncharacterized protein.	40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA; Belongs to the universal ribosomal protein uS13 family.	0.902
ENSCAFP00000058253	RPS5	ENSCAFP00000058253	ENSCAFP00000003434	Uncharacterized protein.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.906

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.866

expected number of edges:

14

PPI enrichment p-value:

1.64e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 43

2.41

4.56

7.38e-10

GO:0006264

Mitochondrial DNA replication

3 of 11

2.7

2.38

4.02e-05

GO:0106074

aminoacyl-tRNA metabolism involved in translational fidelity

3 of 13

2.63

2.3

5.61e-05

GO:0006419

alanyl-tRNA aminoacylation

2 of 2

3.26

1.79

0.00059

GO:0009059

Macromolecule biosynthetic process

9 of 1607

1.01

1.08

9.67e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 45

2.39

4.87

1.31e-10

GO:0140640

Catalytic activity, acting on a nucleic acid

10 of 542

1.53

2.99

6.88e-12

GO:0140098

Catalytic activity, acting on RNA

7 of 336

1.58

2.47

7.14e-08

GO:0002161

aminoacyl-tRNA editing activity

3 of 15

2.56

2.35

4.18e-05

GO:0000049

tRNA binding

4 of 94

1.89

1.99

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 12

2.66

2.21

8.39e-05

GO:0005760

Gamma DNA polymerase complex

2 of 3

3.09

1.64

0.0011

GO:0042645

Mitochondrial nucleoid

3 of 40

2.14

1.54

0.0011

GO:0005739

Mitochondrion

7 of 1640

0.89

0.71

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31610802

(2019) Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia.

4 of 17

2.64

2.58

1.63e-05

PMID:29579307

(2018) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

3 of 11

2.7

1.58

0.0013

PMID:26109058

(2015) Nuclear respiratory factor 2 induces SIRT3 expression.

3 of 20

2.44

1.33

0.0035

PMID:22386318

(2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.

3 of 19

2.46

1.33

0.0035

PMID:37148543

(2023) Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.

3 of 23

2.38

1.32

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1857

Aminoacyl-tRNA biosynthesis

6 of 30

2.56

5.3

4.26e-11

CL:1863

aminoacyl-tRNA synthetase multienzyme complex

4 of 5

3.17

4.61

3.85e-09

CL:2589

Mitochondrial transcription, and Gamma DNA polymerase complex

4 of 11

2.82

4.03

3.24e-08

CL:1899

alanyl-tRNA aminoacylation, and threonyl-tRNA aminoacylation

2 of 5

2.87

1.49

0.0020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00970

Aminoacyl-tRNA biosynthesis

6 of 36

2.49

5.53

8.44e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 13

2.75

3.59

2.06e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 18

2.71

5.07

2.27e-10

KW-0648

Protein biosynthesis

5 of 75

2.09

3.4

5.33e-08

KW-0820

tRNA-binding

3 of 10

2.74

2.95

3.52e-06

KW-0067

ATP-binding

5 of 770

1.08

0.84

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01411

tRNA synthetases class II (A)

2 of 3

3.09

1.22

0.0062

PF09334

tRNA synthetases class I (M)

2 of 8

2.66

1.02

0.0139

PF03129

Anticodon binding domain

2 of 10

2.56

1.02

0.0139

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00991

A conserved domain of 46 amino acids, called WHEP-TRS has been shown PUBMED:1756734 to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in ...

2 of 6

2.79

1.22

0.0061

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 6

2.79

1.22

0.0061

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About