STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
FTOAlpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...] (620 aa)    
Predicted Functional Partners:
ALKBH5
AlkB homolog 5, RNA demethylase.
   
  
 0.868
IRX3
Iroquois homeobox 3.
      
 0.836
METTL14
Methyltransferase like 14; Belongs to the MT-A70-like family.
      
 0.811
YTHDF1
YTH N6-methyladenosine RNA binding protein 1.
   
  
 0.800
YTHDF3
YTH N6-methyladenosine RNA binding protein 3.
   
  
 0.799
YTHDF2
YTH N6-methyladenosine RNA binding protein 2.
   
  
 0.798
MC4R
Melanocortin-4 receptor.
      
 0.776
FOXO1
Forkhead box O1.
   
  
 0.769
CREB1
cAMP responsive element binding protein 1.
   
  
 0.769
METTL3
Methyltransferase like 3; Belongs to the MT-A70-like family.
   
  
 0.730
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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