RBL2 protein (Canis lupus familiaris) - STRING interaction network

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

RBL2

RB transcriptional corepressor like 2. (1162 aa)

Predicted Functional Partners:

E2F4

0.993

E2F3

0.977

E2F5

0.975

E2F2

0.972

TFDP1

0.972

TFDP2

0.969

CDK6

0.961

CCNE1

0.958

CCND1

0.958

CCNE2

0.957

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	CCNE1	ENSCAFP00000061968	ENSCAFP00000011293	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Cyclin E1; Belongs to the cyclin family.	0.606
CCND1	CCNE2	ENSCAFP00000061968	ENSCAFP00000013855	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Cyclin E2; Belongs to the cyclin family.	0.475
CCND1	CDK6	ENSCAFP00000061968	ENSCAFP00000002945	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.999
CCND1	E2F2	ENSCAFP00000061968	ENSCAFP00000019556	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	E2F transcription factor 2.	0.477
CCND1	E2F3	ENSCAFP00000061968	ENSCAFP00000041377	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	E2F transcription factor 3.	0.602
CCND1	RBL2	ENSCAFP00000061968	ENSCAFP00000058501	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	RB transcriptional corepressor like 2.	0.958
CCNE1	CCND1	ENSCAFP00000011293	ENSCAFP00000061968	Cyclin E1; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	0.606
CCNE1	CCNE2	ENSCAFP00000011293	ENSCAFP00000013855	Cyclin E1; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.935
CCNE1	CDK6	ENSCAFP00000011293	ENSCAFP00000002945	Cyclin E1; Belongs to the cyclin family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.995
CCNE1	E2F2	ENSCAFP00000011293	ENSCAFP00000019556	Cyclin E1; Belongs to the cyclin family.	E2F transcription factor 2.	0.803
CCNE1	E2F3	ENSCAFP00000011293	ENSCAFP00000041377	Cyclin E1; Belongs to the cyclin family.	E2F transcription factor 3.	0.773
CCNE1	E2F4	ENSCAFP00000011293	ENSCAFP00000037675	Cyclin E1; Belongs to the cyclin family.	E2F transcription factor 4.	0.685
CCNE1	RBL2	ENSCAFP00000011293	ENSCAFP00000058501	Cyclin E1; Belongs to the cyclin family.	RB transcriptional corepressor like 2.	0.958
CCNE1	TFDP1	ENSCAFP00000011293	ENSCAFP00000063174	Cyclin E1; Belongs to the cyclin family.	Transcription factor.	0.618
CCNE1	TFDP2	ENSCAFP00000011293	ENSCAFP00000044192	Cyclin E1; Belongs to the cyclin family.	Transcription factor Dp-2.	0.621
CCNE2	CCND1	ENSCAFP00000013855	ENSCAFP00000061968	Cyclin E2; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	0.475
CCNE2	CCNE1	ENSCAFP00000013855	ENSCAFP00000011293	Cyclin E2; Belongs to the cyclin family.	Cyclin E1; Belongs to the cyclin family.	0.935
CCNE2	CDK6	ENSCAFP00000013855	ENSCAFP00000002945	Cyclin E2; Belongs to the cyclin family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.962
CCNE2	E2F2	ENSCAFP00000013855	ENSCAFP00000019556	Cyclin E2; Belongs to the cyclin family.	E2F transcription factor 2.	0.800
CCNE2	E2F3	ENSCAFP00000013855	ENSCAFP00000041377	Cyclin E2; Belongs to the cyclin family.	E2F transcription factor 3.	0.811