ITGB8 protein (Canis lupus familiaris) - STRING interaction network

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Score

ITGB8

Integrin beta; Belongs to the integrin beta chain family. (811 aa)

Predicted Functional Partners:

ITGAV

0.995

SRC

0.967

VTN

0.954

PTK2

0.946

FN1

0.926

PXN-2

0.912

CAV1

0.909

PRKCB

0.909

PRKCG

0.908

PRKCA

0.908

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	ITGB8	ENSCAFP00000005060	ENSCAFP00000058857	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Integrin beta; Belongs to the integrin beta chain family.	0.909
CAV1	PRKCA	ENSCAFP00000005060	ENSCAFP00000016686	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.459
CAV1	PTK2	ENSCAFP00000005060	ENSCAFP00000051882	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.442
CAV1	SRC	ENSCAFP00000005060	ENSCAFP00000044994	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.990
FN1	ITGAV	ENSCAFP00000066679	ENSCAFP00000050990	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.991
FN1	ITGB8	ENSCAFP00000066679	ENSCAFP00000058857	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.926
FN1	PTK2	ENSCAFP00000066679	ENSCAFP00000051882	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.766
FN1	SRC	ENSCAFP00000066679	ENSCAFP00000044994	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Tyrosine-protein kinase.	0.718
FN1	VTN	ENSCAFP00000066679	ENSCAFP00000027547	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	SMB domain-containing protein.	0.932
ITGAV	FN1	ENSCAFP00000050990	ENSCAFP00000066679	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.991
ITGAV	ITGB8	ENSCAFP00000050990	ENSCAFP00000058857	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.995
ITGAV	PTK2	ENSCAFP00000050990	ENSCAFP00000051882	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.958
ITGAV	PXN-2	ENSCAFP00000050990	ENSCAFP00000050025	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.905
ITGAV	SRC	ENSCAFP00000050990	ENSCAFP00000044994	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Tyrosine-protein kinase.	0.934
ITGAV	VTN	ENSCAFP00000050990	ENSCAFP00000027547	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	SMB domain-containing protein.	0.978
ITGB8	CAV1	ENSCAFP00000058857	ENSCAFP00000005060	Integrin beta; Belongs to the integrin beta chain family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.909
ITGB8	FN1	ENSCAFP00000058857	ENSCAFP00000066679	Integrin beta; Belongs to the integrin beta chain family.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.926
ITGB8	ITGAV	ENSCAFP00000058857	ENSCAFP00000050990	Integrin beta; Belongs to the integrin beta chain family.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.995
ITGB8	PRKCA	ENSCAFP00000058857	ENSCAFP00000016686	Integrin beta; Belongs to the integrin beta chain family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.908
ITGB8	PRKCB	ENSCAFP00000058857	ENSCAFP00000025992	Integrin beta; Belongs to the integrin beta chain family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.909