STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SNRNP27Small nuclear ribonucleoprotein U4/U6.U5 subunit 27. (235 aa)    
Predicted Functional Partners:
USP39
Ubiquitin specific peptidase 39.
   
 0.960
SART1
Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.
    
 0.945
ETV2
ETS variant 2.
   
  0.908
PRPF4
Pre-mRNA processing factor 4.
   
  0.839
LSM7
Sm domain-containing protein.
   
 0.829
SNRNP40
Small nuclear ribonucleoprotein U5 subunit 40.
   
  0.827
PRPF3
Pre-mRNA processing factor 3.
   
 0.827
PRPF8
Pre-mRNA processing factor 8.
    
 0.804
SNRPD1
Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
   
  0.784
EFTUD2
Elongation factor Tu GTP binding domain containing 2.
   
 0.778
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.