NEK7 protein (Canis lupus familiaris) - STRING interaction network

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Score

NEK7

NIMA related kinase 7; Belongs to the protein kinase superfamily. (338 aa)

Predicted Functional Partners:

NLRP3

0.950

NEK9

0.940

ANKS3

0.884

GSDMD

0.738

PYCARD

0.689

EMG1

0.646

CASP4

0.644

NLRP10

0.641

NLRP14

0.624

YPEL3

0.602

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKS3	NEK7	ENSCAFP00000056174	ENSCAFP00000059247	Ankyrin repeat and sterile alpha motif domain containing 3.	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.884
CASP4	GSDMD	ENSCAFP00000031566	ENSCAFP00000033873	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Gasdermin D.	0.983
CASP4	NEK7	ENSCAFP00000031566	ENSCAFP00000059247	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.644
CASP4	NLRP10	ENSCAFP00000031566	ENSCAFP00000010243	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 10.	0.772
CASP4	NLRP3	ENSCAFP00000031566	ENSCAFP00000015730	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 3.	0.757
CASP4	PYCARD	ENSCAFP00000031566	ENSCAFP00000024803	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	PYD and CARD domain containing.	0.997
EMG1	NEK7	ENSCAFP00000021292	ENSCAFP00000059247	EMG1 N1-specific pseudouridine methyltransferase.	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.646
EMG1	YPEL3	ENSCAFP00000021292	ENSCAFP00000055036	EMG1 N1-specific pseudouridine methyltransferase.	Yippee like 3.	0.853
GSDMD	CASP4	ENSCAFP00000033873	ENSCAFP00000031566	Gasdermin D.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.983
GSDMD	NEK7	ENSCAFP00000033873	ENSCAFP00000059247	Gasdermin D.	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.738
GSDMD	PYCARD	ENSCAFP00000033873	ENSCAFP00000024803	Gasdermin D.	PYD and CARD domain containing.	0.703
NEK7	ANKS3	ENSCAFP00000059247	ENSCAFP00000056174	NIMA related kinase 7; Belongs to the protein kinase superfamily.	Ankyrin repeat and sterile alpha motif domain containing 3.	0.884
NEK7	CASP4	ENSCAFP00000059247	ENSCAFP00000031566	NIMA related kinase 7; Belongs to the protein kinase superfamily.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.644
NEK7	EMG1	ENSCAFP00000059247	ENSCAFP00000021292	NIMA related kinase 7; Belongs to the protein kinase superfamily.	EMG1 N1-specific pseudouridine methyltransferase.	0.646
NEK7	GSDMD	ENSCAFP00000059247	ENSCAFP00000033873	NIMA related kinase 7; Belongs to the protein kinase superfamily.	Gasdermin D.	0.738
NEK7	NEK9	ENSCAFP00000059247	ENSCAFP00000053232	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NIMA related kinase 9.	0.940
NEK7	NLRP10	ENSCAFP00000059247	ENSCAFP00000010243	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NLR family pyrin domain containing 10.	0.641
NEK7	NLRP14	ENSCAFP00000059247	ENSCAFP00000050023	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NLR family pyrin domain containing 14.	0.624
NEK7	NLRP3	ENSCAFP00000059247	ENSCAFP00000015730	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NLR family pyrin domain containing 3.	0.950
NEK7	PYCARD	ENSCAFP00000059247	ENSCAFP00000024803	NIMA related kinase 7; Belongs to the protein kinase superfamily.	PYD and CARD domain containing.	0.689