node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC60 | HCRTR1 | ENSCAFP00000039893 | ENSCAFP00000059469 | Coiled-coil domain containing 60. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.682 |
CCDC60 | HSF2 | ENSCAFP00000039893 | ENSCAFP00000001385 | Coiled-coil domain containing 60. | Heat shock transcription factor 2. | 0.788 |
CCDC60 | PACSIN2 | ENSCAFP00000039893 | ENSCAFP00000058719 | Coiled-coil domain containing 60. | Protein kinase C and casein kinase substrate in neurons 2. | 0.790 |
GNA15 | GRK2 | ENSCAFP00000028444 | ENSCAFP00000017324 | G protein subunit alpha 15. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.665 |
GNA15 | HCRT | ENSCAFP00000028444 | ENSCAFP00000022949 | G protein subunit alpha 15. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | 0.560 |
GNA15 | HCRTR1 | ENSCAFP00000028444 | ENSCAFP00000059469 | G protein subunit alpha 15. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
GNA15 | HCRTR2 | ENSCAFP00000028444 | ENSCAFP00000003376 | G protein subunit alpha 15. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.580 |
GNA15 | PMCH | ENSCAFP00000028444 | ENSCAFP00000010824 | G protein subunit alpha 15. | Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. | 0.552 |
GRK2 | GNA15 | ENSCAFP00000017324 | ENSCAFP00000028444 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | G protein subunit alpha 15. | 0.665 |
GRK2 | HCRT | ENSCAFP00000017324 | ENSCAFP00000022949 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | 0.506 |
GRK2 | HCRTR1 | ENSCAFP00000017324 | ENSCAFP00000059469 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.647 |
GRK2 | HCRTR2 | ENSCAFP00000017324 | ENSCAFP00000003376 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.647 |
GRK2 | PMCH | ENSCAFP00000017324 | ENSCAFP00000010824 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. | 0.499 |
HCRT | GNA15 | ENSCAFP00000022949 | ENSCAFP00000028444 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | G protein subunit alpha 15. | 0.560 |
HCRT | GRK2 | ENSCAFP00000022949 | ENSCAFP00000017324 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.506 |
HCRT | HCRTR1 | ENSCAFP00000022949 | ENSCAFP00000059469 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.981 |
HCRT | HCRTR2 | ENSCAFP00000022949 | ENSCAFP00000003376 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Belongs to the G-protein coupled receptor 1 family. | 0.989 |
HCRT | OXR1 | ENSCAFP00000022949 | ENSCAFP00000064061 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Oxidation resistance 1. | 0.836 |
HCRT | PMCH | ENSCAFP00000022949 | ENSCAFP00000010824 | Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. | Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. | 0.989 |
HCRTR1 | CCDC60 | ENSCAFP00000059469 | ENSCAFP00000039893 | Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. | Coiled-coil domain containing 60. | 0.682 |