STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAB3ARAB3A, member RAS oncogene family. (220 aa)    
Predicted Functional Partners:
RIMS2
Regulating synaptic membrane exocytosis 2.
   
 0.974
VAMP2
V-SNARE coiled-coil homology domain-containing protein.
   
 
 0.937
SYT1
Synaptotagmin 1.
   
 0.922
PCLO
Piccolo presynaptic cytomatrix protein.
   
 
 0.909
RPH3A
Rabphilin 3A.
   
 
 0.863
SLC18A3
Solute carrier family 18 member A3.
   
 
 0.838
SLC17A7
Solute carrier family 17 member 7.
   
 0.834
GDI1
Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
   
 0.793
WDR7
WD repeat domain 7.
   
  
 0.725
SNAP25
Synaptosomal-associated protein; Belongs to the SNAP-25 family.
   
 
 0.705
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.